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Rapid tear screening of diabetic retinopathy by a detachable surface acoustic wave enabled immunosensor.
Anal Chim Acta
October 2024
Department of Biomedical Engineering, National Cheng Kung University, Tainan, 701, Taiwan; Medical Device Innovation Center, National Cheng Kung University, Tainan, 701, Taiwan. Electronic address:
Article Synopsis
- * A new study presents a surface acoustic wave (SAW) microchip that enhances the detection of DR through a noninvasive analysis of protein biomarkers in tear fluid, making the process quicker and more effective.
- * Early tests show the SAW microchip's results align well with established methods, indicating it could significantly improve how DR is diagnosed and managed in diabetic patients, helping to prevent vision loss.
Detachable acoustofluidic droplet-sorter.
Anal Chim Acta
September 2024
Department of Biomedical Engineering, National Cheng Kung University, Tainan, 701, Taiwan; Medical Device Innovation Center, National Cheng Kung University, Tainan, 701, Taiwan. Electronic address:
Background: Cell sorting is crucial in isolating specific cell populations. It enables detailed analysis of their functions and characteristics and plays a vital role in disease diagnosis, drug discovery, and regenerative medicine. Fluorescence-activated cell sorting (FACS) is considered the gold standard for high-speed single-cell sorting.
View Article and Find Full Text PDFStudy of Risk Factors for the Presence of Interdigital Nevi of the Feet.
Actas Dermosifiliogr
May 2024
Servicio de Dermatología, Hospital General Universitario Dr. Balmis, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, España; Departamento de Medicina Clínica, Universidad Miguel Hernández, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, España.
Article Synopsis
- A study was conducted to analyze the relationship between interdigital acquired melanocytic nevi (AMN) on the foot and total AMN counts in the body, focusing on various factors linked to melanoma risk.
- The research involved 255 patients aged 18 and older, examining nevi size and employing statistical models to evaluate associations between variables.
- Findings suggest that having IDNf is strongly linked to a higher number of plantar nevi and total AMN, indicating that the foot's anatomical features, which don’t receive much sun exposure, may influence nevi counts.
Correlation of lesion severity with bacterial changes in Treponeme-Associated Hoof Disease from free-roaming wild elk (Cervus canadensis).
Anim Microbiome
April 2024
Infectious Bacterial Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service- USDA, 1920 Dayton Ave, 50010, Ames, IA, USA.
Background: Treponeme-Associated Hoof Disease (TAHD) is a polybacterial, multifactorial disease affecting free-ranging wild elk (Cervus canadensis) in the Pacific Northwest. Previous studies have indicated a bacterial etiology similar to digital dermatitis in livestock, including isolation of Treponema species from lesions. The lesions appear to progress rapidly from ulcerative areas in the interdigital space or along the coronary band to severe, ulcerative, necrotic, proliferative lesions under-running the hoof wall, perforating the sole, and contributing to hoof elongation, deformity, and overgrowth.
View Article and Find Full Text PDFGenome-wide association and functional genomic analyses for various hoof health traits in North American Holstein cattle.
J Dairy Sci
April 2024
Centre for Genetic Improvement of Livestock, Department of Animal Biosciences, University of Guelph, Guelph, ON, N1G 2W1, Canada; Department of Animal Sciences, Purdue University, West Lafayette, IN 47907. Electronic address:
Article Synopsis
- Hoof diseases in dairy cattle significantly impact animal welfare and farming economics, and addressing these issues requires enhanced management and breeding practices, backed by genetic research.
- This study utilized high-density genetic markers from North American Holsteins to conduct genome-wide association studies for 8 hoof-related traits and a hoof health index, identifying numerous significant genetic markers linked to these conditions.
- The research uncovered important genomic insights, indicating that hoof health traits are connected to other critical health and productivity traits in cattle, and highlighted potential candidate genes related to bone development and immune response.
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