AI Article Synopsis
- The study investigates the roles of β-catenin and L1CAM in type I Endometrial Carcinoma using 49 tissue samples to assess their impact on prognostic factors.
- Results indicate that out of the samples, 34.7% presented lymphovascular space invasion (LVSI), with a significant correlation found between β-catenin/L1CAM expression and both LVSI and metastasis (p <0.05).
- The findings suggest that β-catenin and L1CAM are important biomarkers for predicting the progression of type I Endometrial Carcinoma, specifically regarding their involvement in metastasis and tumor development.
Article Abstract
Objective: The aim of this study is to evaluate the expression of β-catenin and L1CAM in the type I of Endometrial Carcinoma.
Material And Methods: This study was an analytical study with a cross-sectional design using 49 samples of type I Endometrial Carcinoma. Immunohistochemical method was used to evaluate the expression of β-catenin and L1CAM related to two significant prognostic parameters i.e., lymphovascular space invasion (LVSI) and metastases event of type I Endometrial Carcinoma samples.
Results: From all samples collected, based on the presence of LVSI, there were 17 cases (34.7%) with LVSI and 32 (65.3%) no LVSI. Among them, there were 13 cases that included lymph node or omental samples in type I Endometrial Carcinoma, 5 (38.5%) cases of metastasis, and 8 (61.5%) cases that did not metastasize. The statistical results showed that there was a significant correlation between β-catenin and L1CAM expressions examined from tumor cells with lymphovascular space invasion and the presence of metastases in the type I Endometrial Carcinoma (p <0.05).
Conclusion: This study suggest that the positive expression of β-catenin together with L1CAM can participate in the development of tumor cells in type I Endometrial Carcinoma, in its ability to involve lymphovascular space invasion, and metastases to other sites. Our results indicate that both of β-catenin and L1CAM are prominent biomarkers for the prognosis of type I Endometrial Carcinoma.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352722 | PMC |
| http://dx.doi.org/10.31557/APJCP.2023.24.4.1413 | DOI Listing |
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