•Recent findings of cryo-EM structures of mammalian FF-ATPase.•The membrane-embedded domain of the FF-ATPase and the permeability transition pore.•The Ca-activated F-ATPase role in the mPTP is consistent with recent cryo-EM findings.•The membrane-embedded FO participates in mPTP formation in mammalian mitochondria.•Conformational changes within FO modify the inner mitochondrial membrane shape.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074935 | PMC |
| http://dx.doi.org/10.1016/j.bbadva.2020.100001 | DOI Listing |
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