Within the addiction field, some advocates support a suite of de-regulatory policies that aim to reduce harm by providing people who use drugs with a "safe supply" of pharmaceutical-grade medications. Such initiatives have commenced without the evidence standards normally used to label medication provision as "safe." This perspective suggests that continued debate and research in this area acknowledge the potential toxicity of any provided safe supply medications and highlights that these initiatives could result in an unhelpful reduction in interactions between people who use drugs and health care professionals.
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http://dx.doi.org/10.15288/jsad.23-00054 | DOI Listing |
Heliyon
January 2025
Cooperative Major in Advanced Biomedical Sciences of Tokyo Women's Medical University and Waseda University, 2-2, TWIns, Wakamatsu-cho, Shinjuku-ku, Tokyo, 162-8480, Japan.
Due to the spread of SARS-CoV-2 virus infectious disease (COVID-19), blood donation events had to be cancelled, and there were concerns about a decrease in the number of blood donors from late February 2020 in Japan. The purpose of this study is to investigate the numbers of whole blood donation, manufacture and inventory adjustment of red blood cell (RBC) products at the Japanese Red Cross Society (JRCS), and to evaluate the effects of COVID-19 on the donation of blood and the supply of RBC products to medical institutions for transfusion medicine in Japan. We focused on RBC products, which are the most frequently used blood products and are easily reflected under the spread of COVID-19.
View Article and Find Full Text PDFHeliyon
July 2024
School of Petroleum Engineering, Chongqing University of Science & Technology, Chongqing, 401331, China.
City gas stations (CGSs) play a crucial role in ensuring a stable and safe supply of natural gas to urban users. However, as the service time of stations increases and the performance of components deteriorates, concerns about the safety and reliability of these station have grown among operators and local government authorities. This paper proposes a fuzzy reliability assessment methodology for CGSs that considers the polymorphism of component faults and the uncertainties associated with fault relationships, failure probabilities, and fault magnitudes.
View Article and Find Full Text PDFJ Biol Chem
January 2025
Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK. Electronic address:
The proteasome is considered an excellent drug target for many infectious diseases as well as cancer. Challenges with robust and safe supply of proteasomes from infectious agents, lack of structural information, and complex pharmacology due to multiple active sites have hampered progress in the infectious disease space. We recombinantly expressed the proteasome of the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease, and demonstrate pharmacological equivalence to the native T.
View Article and Find Full Text PDFDrug Alcohol Depend
November 2024
Department of Criminal Justice and Criminology, Georgia State University, Atlanta, GA, USA.
Background And Aims: The misrepresentation of illicit drugs in unregulated markets increases the risk of adverse health events. This study analyzed drug checking data to compare represented, expected, and actual content of alleged MDMA samples, estimate trends in the quality of the MDMA supply, document the presence of adulterants, compare patterns of adulteration, and validate drug checking against law enforcement data.
Method: The study analyzed 4719 alleged MDMA samples submitted to the DrugsData drug checking service between 1999-2023.
Cureus
August 2024
Transfusion Medicine, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, IND.
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