We report herein a straightforward transfer of a free amino group (NH ) from a commercially available nitrogen source to unfunctionalized, native carbonyls (amides and ketones) resulting in direct α-amination. Primary α-amino carbonyls are readily produced under mild conditions, further enabling diverse in situ functionalization reactions-including peptide coupling and Pictet-Spengler cyclization-that capitalize on the presence of the unprotected primary amine.
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| http://dx.doi.org/10.1002/anie.202304990 | DOI Listing |
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