AI Article Synopsis
- A study analyzed 609 hospitalized Japanese COVID-19 patients to understand the prevalence and severity of gastrointestinal (GI) symptoms.
- Among the patients, 36% exhibited GI symptoms, with diarrhea being the most common, though the severity of GI issues did not correlate with the severity of COVID-19 infection.
- Timing of symptoms showed that in patients with both GI and respiratory symptoms, about half had respiratory symptoms first, while others experienced simultaneous or GI symptoms before respiratory ones.
Article Abstract
Background: GI symptoms are common in acute COVID-19 patients. This study aimed to characterize the GI symptoms occurring in Japanese COVID-19 patients.
Methods: This retrospective single-center cohort study included 751 hospitalized acute COVID-19 patients. The primary outcomes were the frequency and severity of GI symptoms. The secondary outcomes included the association between COVID-19 severity and GI symptoms and the timing of GI symptom onset.
Results: After exclusion, the data of 609 patients were analyzed. The median age was 62 years, and 55% were male. The median time from initial symptom onset to admission was five days. On admission, 92% of the patients had fever, 35.1% had fatigue, 75% had respiratory symptoms, and 75% had pneumonia. The sample included patients with mild (19%), moderate (59%), and severe COVID-19 (22%). A total of 218 patients (36%) had GI symptoms, of which 93% were classified as grade 1/2; 170 patients had both respiratory and GI symptoms. Diarrhea was the most frequent GI symptom, occurring in 170 patients, followed by anorexia in 73 patients and nausea/vomiting in 36 patients, and abdominal pain in 8 patients. There was no significant relationship between COVID-19 severity and GI symptoms. Among COVID-19 patients with both GI and respiratory symptoms, 48% had respiratory symptoms preceding GI symptoms, 25% had GI symptoms preceding respiratory symptoms and 27% had a simultaneous onset of respiratory and GI symptoms.
Conclusion: Thirty-six percent of the Japanese COVID-19 patients had GI symptoms; diarrhea was the most frequent GI symptom but did not predict severe COVID-19.
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| http://dx.doi.org/10.1080/00365521.2023.2204387 | DOI Listing |
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