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Long-term allograft survival is limited by humoral-associated chronic allograft rejection, suggesting inadequate constraint of humoral alloimmunity by contemporary immunosuppression. Heterogeneity in alloreactive B cells and the incomplete definition of which B cells participate in chronic rejection in immunosuppressed transplant recipients limits our ability to develop effective therapies. Using a double-fluorochrome single-HLA tetramer approach combined with single-cell culture, we investigated the B-cell receptor (BCR) repertoire characteristics, avidity, and phenotype of donor HLA-DQ reactive B cells in a transplant recipient with end-stage donor specific antibody (DSA)-associated cardiac allograft vasculopathy while receiving maintenance immunosuppression (tacrolimus, mycophenolate mofetil, prednisone).
View Article and Find Full Text PDFFirst ABO-Incompatible Pediatric Kidney Transplant in South Africa-A Case Report.
Pediatr Transplant
February 2025
University of Cape Town, Cape Town, South Africa.
Background: Blood group incompatibility previously represented an obstacle to living related donor (LRD) options; desensitization modalities have expanded LRD options. ABO-incompatible kidney transplants have been successful in adults and pediatric liver transplants, but to date not yet in pediatric kidney transplants in South Africa.
Case Report: Patient X is a 5 year old male with end-stage kidney failure due to Posterior Urethral Valves, requiring peritoneal dialysis pre-transplant.
Outcomes of ABO-incompatible kidney transplants with very high isoagglutinin titers: a single-center experience and literature review.
Front Immunol
December 2024
Nephrology, Hemodialysis, Apheresis and Kidney Transplantation Department, Grenoble University Hospital, Grenoble, France.
Background: ABO-incompatible kidney transplantation (ABOi-KTx) represents a possible solution to address the shortage of kidney donors. However, these transplants present immunological challenges, particularly when isoagglutinin titers are elevated pretransplant.
Methods: Single-center retrospective study describing clinical and biological outcomes of 8 patients who underwent ABOi-KTx with initial isoagglutinin titers ≥ 1/512.
A complex and severe encephalitis associated with four co-existing neuronal cell-surface autoantibodies.
J Neuroimmunol
December 2024
Department of Neurology, St. Vincent's University Hospital, Elm Park, Dublin, Ireland. Electronic address:
Many forms of autoimmune encephalitis are mediated by neuronal cell-surface directed autoantibodies. The co-occurrence of four neuronal cell-surface antibodies in a single patient is exceptionally rare. We report a patient who had a severe encephalitis associated with antibodies to NMDA, Glycine, GABA and GABA receptors.
View Article and Find Full Text PDFImpact of induction agents and maintenance immunosuppression on torque teno virus loads and year-one complications after kidney transplantation.
Front Immunol
November 2024
Department of Nephrology, University Hospital Heidelberg, Heidelberg, Germany.
Article Synopsis
- Torque teno virus load (TTVL) is being studied as a way to measure immune health in kidney transplant patients, particularly how different medications affect TTVL levels.
- In a study of 134 patients, TTVL levels peaked at 90 days post-transplant and were significantly higher in those who received anti-thymocyte globulin (ATG) compared to interleukin-2 receptor antagonists (IL2-RA).
- Higher TTVL levels may indicate a greater risk of infections for patients, though this trend wasn't statistically significant, suggesting that monitoring TTVL could help manage immunosuppressive therapy post-transplant.
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