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Incorporation of synthetic water-soluble curcumin polymeric drug within calcium phosphate cements for bone defect repairing. | LitMetric

AI Article Synopsis

  • Modified calcium phosphate cement (CPC) has limitations in bone regeneration, necessitating the development of enhanced materials with better degradation properties.
  • The study introduces a composite material made from curcumin (CUR)-hyaluronic acid (HA) and glucose microparticles (GMPs) that improves the porosity and controlled release of osteogenic substances while maintaining good mechanical strength.
  • This CUR-HA/GMP/CPC composite promotes bone regeneration by enhancing stem cell differentiation and accelerating vascularization when implanted in bone defects, offering potential for clinical application in repairing bone injuries.

Article Abstract

Modified macroporous structures and active osteogenic substances are necessary to overcome the limited bone regeneration capacity and low degradability of self-curing calcium phosphate cement (CPC). Curcumin (CUR), which possesses strong osteogenic activity and poor aqueous solubility/bioavailability, esterifies the side chains in hyaluronic acid (HA) to form a water-soluble CUR-HA macromolecule. In this study, we incorporated the CUR-HA and glucose microparticles (GMPs) into the CPC powder to fabricate the CUR-HA/GMP/CPC composite, which not only retained the good injectability and mechanical strength of bone cements, but also significantly increased the cement porosity and sustained release property of CUR-HA . CUR-HA incorporation greatly improved the differentiation ability of bone marrow mesenchymal stem cells (BMSCs) to osteoblasts by activating the RUNX family transcription factor 2/fibroblast growth factor 18 (RUNX2/FGF18) signaling pathway, increasing the expression of osteocalcin and enhancing the alkaline phosphatase activity. In addition, implantation of CUR-HA/GMP/CPC into femoral condyle defects dramatically accelerated the degradation rate of cement and boosted local vascularization and osteopontin protein expression, and consequently promoted rapid bone regeneration. Therefore, macroporous CPC based composite cement with CUR-HA shows a remarkable ability to repair bone defects and is a promising translational application of modified CPC in clinical practice.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127129PMC
http://dx.doi.org/10.1016/j.mtbio.2023.100630DOI Listing

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