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http://dx.doi.org/10.3389/fped.2023.1181390 | DOI Listing |
Br J Dev Psychol
January 2025
Graduate School Education, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
J Hand Surg Eur Vol
January 2025
Department of Orthopaedic Surgery, Queen Elizabeth University Hospital, Glasgow, UK.
This article explores the background to the concept of levels of evidence and their role in promoting the principles of evidence-based medicine within hand surgery. The requires allocation of a level of evidence to each full-length clinical research article. The system employed by the Journal is described, together with discussion of limitations and difficulties in application.
View Article and Find Full Text PDFBrain Sci
January 2025
Behavioral and Robotic Neurorehab Unit, IRCCS Centro Neurolesi "Bonino Pulejo", 98123 Messina, Italy.
It was a great pleasure to be the guest editor for the Special Issue on understanding the use of rehabilitation devices in neurological diseases [...
View Article and Find Full Text PDFFront Cell Dev Biol
January 2025
Department of Cell and Cancer Biology, College of Medicine and Life Sciences, The University of Toledo, Toledo, OH, United States.
Heat Shock Factor 1 (HSF1) is a major transcriptional factor regulating the heat shock response and has become a potential target for overcoming cancer chemoresistance. This review comprehensively examines HSF1's role in chemoresistance and its potential as a therapeutic target in cancer. We explore the complex, intricate mechanism that regulates the activation of HSF1, HSF1's function in promoting resistance to chemotherapy, and the strategies used to manipulate HSF1 for therapeutic benefit.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
January 2025
Department of Obstetrics and Gynaecology, Assiut University, Assiut, Egypt.
Oxidative stress (OS) is established as a key factor in the etiology of both male and female infertility, arising from an imbalance between reactive oxygen species (ROS) production and the endogenous antioxidant (AOX) defenses. In men, OS adversely affects sperm function by inducing DNA damage, reducing motility, significantly impairing sperm vitality through plasma membrane peroxidation and loss of membrane integrity, and ultimately compromising overall sperm quality. In women, OS is implicated in various reproductive disorders, including polycystic ovary syndrome, endometriosis, and premature ovarian failure, leading to diminished oocyte quality, disrupted folliculogenesis, and poorer reproductive outcomes.
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