AI Article Synopsis
- - Primary anorectal melanoma is a rare and aggressive cancer with a poor prognosis, often diagnosed late due to advanced stages at presentation.
- - A 57-year-old woman with localized scleroderma presented with a mass sensation and was eventually diagnosed with primary rectal melanoma, leading to neoadjuvant radiotherapy and subsequent surgical resection.
- - Treatment options are limited due to the rarity of the disease, but emerging therapies like anti-CTLA4 drugs show promise; however, the lack of research and guidelines complicates optimal management strategies.
Article Abstract
Unlabelled: Primary anorectal melanoma is an extremely rare malignancy of the gastrointestinal tract with a very poor prognosis. Due to the late presentation, most patients with primary anorectal melanoma are diagnosed at advanced stages. Scleroderma is an autoimmune disease characterized by fibrosis of the skin and visceral organs. There is an increased risk of developing cancer in scleroderma patients.
Case Presentation: A 57-year-old Syrian female diagnosed with localized scleroderma complained of a sensation of a mass in her anal area. She was diagnosed with primary rectal melanoma and was put on neoadjuvant radiotherapy. Following the radiotherapy, the endoscopy revealed several black lesions in her anal canal, and thus abdominoperineal resection was conducted.
Discussion And Conclusion: Malignant melanoma can occur in unsuspected locations such as the anal canal. Novel therapies like anti-CTLA4 drugs have proven efficient in controlling the disease. The lack of data in the literature on this malignancy and the absence of guidelines make it challenging for an optimal approach.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129247 | PMC |
| http://dx.doi.org/10.1097/MS9.0000000000000321 | DOI Listing |
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