AI Article Synopsis
Article Abstract
Aims: Patients with chest pain and normal coronary angiogram [angina with normal coronary arteries (ANOCA)] constitute a therapeutic problem with considerable functional limitation and reduced quality of life. The aims of the current pilot study were to (i) explore if a structured aerobic high-intensity interval training (HIT) program for 12 weeks was feasible in patients with ANOCA, and (ii) to assess mechanisms related to symptoms in this population.
Methods And Results: Sixteen patients with ANOCA underwent a 3-month aerobic HIT program with one-to-one monitored exercise sessions on treadmill in a 4 min × 4 manner, three times a week. Four patients served as controls. Coronary flow velocity reserve (CFVR) transthoracic Doppler, flow-mediated vasodilation (FMD) and VO was measured at baseline and after 12 weeks. The average attendance to training sessions was 82.3% ± 10.1 (56-94). CFVR in the training group increased from 2.50 ± 0.48 to 3.04 ± 0.71 ( < 0.001) whereas FMD increased from 4.19 ± 2.42% to 8.28 ± 2.85% ( < 0.001). Improvement in CFVR correlated with the relative improvement in FMD ( = 0.45, = 0.047). This was associated with an increase in VO from 28.75 ± 6.51 mL/kg/min to 31.93 ± 6.46 mL/kg/min ( < 0.001).
Conclusion: A 3-month program of monitored HIT was feasible, with high adherence resulting in improved functional capacity in patients with ANOCA. CFVR improved and this improvement was associated with improved FMD.
Clinicaltrialsgov Identifier: NCT02905630.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127938 | PMC |
| http://dx.doi.org/10.1093/ehjopen/oead030 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
MiRNA-34a, miRNA-145, and miRNA-222 Expression, Matrix Metalloproteinases, TNF-α and VEGF in Patients with Different Phenotypes of Coronary Artery Disease.
Int J Mol Sci
December 2024
Department of Hospital Therapy No 1, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia.
The development of different phenotypes of coronary artery (CA) lesions is regulated via many various factors, such as pro-inflammatory agents, zinc-dependent endopeptidases, growth factors and circulating microRNAs (miRs). To evaluate the expression levels of miR-34a, miR-145 and miR-222, tumor necrosis factor α (TNF-α), matrix metalloproteinases (MMP-1, -9, -13 and -14) and vascular endothelial growth factor (VEGF) in patients with different phenotypes of coronary artery disease (CAD): ischemia/angina with non-obstructive coronary arteries (INOCA/ANOCA) and obstructive CAD (oCAD) compared with a control group. This cross-sectional observational study included 157 subjects with a verified CAD diagnosis (51 patients with INOCA, 76 patients with oCAD and 30 healthy volunteers).
View Article and Find Full Text PDFPrevalence of Arrhythmias in Patients With Coronary Microvascular Dysfunction.
Catheter Cardiovasc Interv
December 2024
Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, District of Columbia, USA.
Background: Coronary microvascular dysfunction (CMD) is an important cause of angina with nonobstructive coronary arteries (ANOCA). It is unclear whether CMD is associated with arrhythmia.
Aims: This study aimed to evaluate the prevalence of arrhythmias in patients with ANOCA and CMD compared to those in patients with ANOCA without CMD.
Diagnostic Yield of Comprehensive Coronary Function Testing in Patients with Angina and Unobstructed Coronary Arteries: Endotype Characterisation and Clinical Implications.
Eur Cardiol
November 2024
Department of Cardiology and Angiology, Robert Bosch Hospital Stuttgart, Germany.
Article Synopsis
- Coronary functional disorders (CFD) significantly contribute to angina in patients with non-obstructed coronary arteries (ANOCA), with different endotypes identified, such as microvascular spasm and coronary microvascular dysfunction (CMD).
- A study involving 89 ANOCA patients using comprehensive coronary functional testing (CFT) found that 91% had at least one disorder, with microvascular spasm being the most common (61%).
- The results highlighted that isolated CMD is rare and emphasized the necessity of spasm testing for diagnosing and characterizing CFD in ANOCA patients.
Utilizing Invasive Coronary Functional Testing in a Coronary Microvascular and Vasomotor Dysfunction Program: Methods and Considerations.
Catheter Cardiovasc Interv
December 2024
Carl and Edyth Lindner Center for Research and Education, The Christ Hospital Health Network, Cincinnati, Ohio, USA.
Background: Coronary microvascular and vasomotor dysfunction (CMVD) is associated with a threefold increased risk of major adverse cardiovascular events (MACE) and is the primary mechanism responsible for angina/ischemia in patients with nonobstructive coronary artery disease (ANOCA/INOCA). Proper assessment for CMVD is vital to provide targeted treatment and improve patient outcomes. Invasive coronary functional testing (ICFT) is the "gold standard," for CMVD assessment and can be used to diagnose all endotypes.
View Article and Find Full Text PDFCoronary Sinus Reducer Improves Angina, Quality of Life, and Coronary Flow Reserve in Microvascular Dysfunction.
JACC Cardiovasc Interv
December 2024
Mayo Clinic, Rochester, Minnesota, USA. Electronic address:
Background: Coronary microvascular dysfunction (CMD) is a common cause of angina with no obstructive coronary artery disease (ANOCA), and effective treatment options are limited.
Objectives: This study aims to assess the safety and efficacy of the coronary sinus (CS) Reducer (Neovasc, Inc/Shockwave Medical) for treatment of angina in patients with CMD.
Methods: This Phase II trial enrolled 30 patients with ANOCA, invasively diagnosed CMD, and Canadian Cardiovascular Society (CCS) class 3 to 4 angina despite medical therapy.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!