AI Article Synopsis
- Cytomegalovirus (CMV) is linked to congenital infections, and this study aimed to validate a new IgM titer cutoff for detecting primary infections in pregnant women.
- Over two time periods (2013-2017 and 2017-2019), researchers screened a total of nearly 32,000 women for CMV antibodies, with findings showing similar rates of IgM positives and congenital CMV cases across the two periods.
- The revised IgM cutoff effectively enhances screening for primary CMV infections in mothers and newborns, though more research is needed on other testing methods beyond the Denka assay.
Article Abstract
Cytomegalovirus (CMV) is associated with congenital infections. We aimed to validate the revised CMV immunoglobulin (Ig) M titer cutoff for IgG avidity measurements as a reflex test in maternal screening to identify women with primary CMV infection and newborn congenital cytomegalovirus (cCMV). We screened maternal CMV antibodies (the Denka assay) in Japan, from 2017 to 2019, using a revised IgM cutoff (≥4.00 index). Participants were tested for IgG and IgM antibodies, and for IgG avidity if IgM levels exceeded the cutoff. We compared these with corresponding results from 2013 to 2017 based on the original cutoff (≥1.21) and recalculated using the revised cutoff. Newborn urine CMV DNA tests were performed for women with low avidity (≤35.0%). Among 12,832 women screened in 2017-2019, 127 (1.0%) had IgM above the revised cutoff. Thirty-five exhibited low avidity, and seven infants developed cCMV. Of 19,435 women screened in 2013-2017, 184 (1.0%) had IgM above the revised cutoff, 67 had low avidity, and 1 had cCMV. The 2017-2019 results were not significantly different from the 2013-2017 results. The revised IgM cutoff improves maternal screening in identifying primary infection and newborn cCMV; however, further study related to other assays than Denka is required.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143041 | PMC |
| http://dx.doi.org/10.3390/v15040962 | DOI Listing |
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