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Laboratory Evaluation and Field Testing of Dengue NS1 and IgM/IgG Rapid Diagnostic Tests in an Epidemic Context in Senegal. | LitMetric

AI Article Synopsis

  • Dengue cases in Senegal are on the rise, making rapid diagnostic tests (RDTs) essential for managing outbreaks effectively.
  • The study assessed the performance of Dengue NS1 and IgM/IgG RDTs in both laboratory and field settings, showing high sensitivity and specificity for diagnosing dengue.
  • Results indicated that RDTs are valuable tools for quick diagnosis during outbreaks, even without a confirmatory lab test, supporting their use in areas with high dengue prevalence.

Article Abstract

In Senegal, the burden of dengue is increasing and expanding. As case management and traditional diagnostic techniques can be difficult to implement, rapid diagnostic tests (RDTs) deployed at point of care are ideal for investigating active outbreaks. The aim of this study was to evaluate the diagnostic performance of the Dengue NS1 and Dengue IgM/IgG RDTs on the serum/plasma samples in a laboratory setting and in the field. During laboratory evaluation, performance of the NS1 RDT was assessed using NS1 ELISA as the gold standard. Sensitivity and specificity were 88% [75-95%] and 100% [97-100%], respectively. Performance of the IgM/IG RDT was assessed using the IgM Antibody Capture (MAC) ELISA, indirect IgG, and PRNT as gold standards. The IgM and IgG test lines respectively displayed sensitivities of 94% [83-99%] and 70% [59-79%] and specificities of 91% [84-95%] and 91% [79-98%]. In the field, the Dengue NS1 RDT sensitivity and specificity was 82% [60-95%] and 75% [53-90%], respectively. The IgM and IgG test lines displayed sensitivities of 86% [42-100%] and 78% [64-88%], specificities of 85% [76-92%] and 55% [36-73%], respectively. These results demonstrate that RDTs are ideal for use in a context of high prevalence or outbreak setting and can be implemented in the absence of a confirmatory test for acute and convalescent patients.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143717PMC
http://dx.doi.org/10.3390/v15040904DOI Listing

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