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[Arrhythmias and conduction block in the newborns of mothers who had received long-term tocolytic therapy].

Ginekol Pol

August 1996

Zakładu Propedeutyki Chorób Dzieci Katedry Chorób Dzieci PAM w Szczecinie.

Serial electrocardiograms (ECGs) were studied prospectively in 48 newborns exposed in utero to prolonged tokolytic therapy to beta-sympathomimetics and in 30 newborns non-exposed in utero to beta-mimetics. Duration of exposure to tocolysis was at least 7 days, mean 51 +/- 36 days. The ECGs were made in 1-st and 3-rd day of life.

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In pregnancy calcium antagonism is of great importance. The uterus-relaxing properties of verapamil are well known, diltiazem shows an excellent tokolytic efficacy and is also effective as hypotensive in pregnancy-induced hypotension. In contrast to verapamil and diltiazem the dihydropyridines were not clinically successful as tokolytic or hypotensive in pregnancy.

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The effect on renal function of a combination of a beta 2 receptors stimulating tokolytic agent (Fenoterol) with a so-called cardioselective beta 1 blocker (Metoprolol) which is able to antagonise the cardiac side effects of beta 2 stimulation, was examined in femaLe rabbits in a 24-hour test. Infusing 31.5 ml/h isotonic solution, 20 micrograms/kg/min Fenoterol and 3.

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