The applicability of different solvent-free approaches leading to the amorphization of active pharmaceutical ingredients (APIs) was tested. Ethenzamide (ET), an analgesic and anti-inflammatory drug, and two ethenzamide cocrystals with glutaric acid (GLU) and ethyl malonic acid (EMA) as coformers were used as pharmaceutical models. Calcinated and thermally untreated silica gel was applied as an amorphous reagent. Three methods were used to prepare the samples: manual physical mixing, melting, and grinding in a ball mill. The ET:GLU and ET:EMA cocrystals forming low-melting eutectic phases were selected as the best candidates for testing amorphization by thermal treatment. The progress and degree of amorphousness were determined using instrumental techniques: solid-state NMR spectroscopy, powder X-ray diffraction, and differential scanning calorimetry. In each case, the API amorphization was complete and the process was irreversible. A comparative analysis of the dissolution profiles showed that the dissolution kinetics for each sample are significantly different. The nature and mechanism of this distinction are discussed.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142476 | PMC |
| http://dx.doi.org/10.3390/pharmaceutics15041234 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluation of the Microstructure and Properties of As-Cast Magnesium Alloys with 9% Al and 9% Zn Additions.
Materials (Basel)
December 2024
Faculty of Mechanical Engineering, Czech Technical University in Prague, 16629 Prague, Czech Republic.
The need to reduce energy consumption means that it is necessary to reduce the weight of vehicles. However, a thick wall of massive elements promotes the formation of casting defects, which must be removed by either plastic processing (straightening) or welding methods (surface and internal discontinuities). Basic alloys contain Al and Zn as the main alloying elements.
View Article and Find Full Text PDFMultiple Preheating Processes for Suppressing Liquefaction Cracks in IN738LC Superalloy Fabricated by Electron Beam Powder Bed Fusion (EB-PBF).
Materials (Basel)
November 2024
Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China.
Article Synopsis
- * A new multiple preheating process using dual-band infrared measurement reduces surface cooling by 28.6% and lowers carbide and boride precipitation, significantly decreasing the risk of liquefaction cracking.
- * This innovative technique allows for crack-free forming at lower preheating temperatures (1000 °C) and improves the powder recycling rate, leading to the successful fabrication of durable IN738 components.
Crystallization-Controlled Structure and Thermal Properties of Biobased Poly(Ethylene2,5-Furandicarboxylate).
Polymers (Basel)
October 2024
Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz, Poland.
Crystallization-controlled structure and thermal properties of biobased poly(ethylene 2,5-furandicarboxylate) (PEF) were studied. The cold-crystallization temperature controlled the structure and thermal properties of the biobased PEF. The melting was complex and evidenced the presence of a significant fraction of less-stable crystals with a low melting temperature that linearly increased with , which formed already during the early stages of crystallization, together with those melting at a higher temperature.
View Article and Find Full Text PDFDesign and demonstration of a temperature-resistant aptamer structure for highly sensitive mercury ion detection with BioFETs.
Talanta
February 2025
Institute of Nanoengineering and Microsystems, National Tsing Hua University, Hsinchu, Taiwan; Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu, Taiwan; College of Semiconductor Research, National Tsing Hua University, Hsinchu, Taiwan. Electronic address:
Article Synopsis
- - This study created a temperature-resistant aptamer paired with electric double-layer Field-Effect Transistors (FETs) for detecting mercury ions effectively, leveraging the aptamer's stable hairpin structure that enhances sensitivity.
- - Two aptamer sequences with varying melting temperatures were tested, revealing that the one with a higher melting temperature demonstrated significantly improved detection sensitivity, achieving a remarkable limit of detection of 4.68 × 10 M, much lower than previous methods.
- - The research emphasized that both the thermal properties of aptamers and the surrounding temperature are crucial for optimizing sensor performance, particularly in differentiating between mercury and other heavy metals like arsenic and lead.
Targeted Inhibition of p21 Promotes the Growth of Breast Cancer Cells and Impairs the Tumor-Killing Effect of the Vaccinia Virus.
J Breast Cancer
October 2024
College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China.
Article Synopsis
- The study investigates how knocking down the p21 gene affects breast cancer cells and interacts with the efficacy of a modified vaccinia virus used for cancer therapy.
- It finds that reducing p21 levels increases the growth and migration of certain breast cancer cells while also diminishing the virus's ability to kill these cancer cells in both lab and mouse models.
- The results suggest that the presence of p21 is critical for enhancing the therapeutic effects of the vaccinia virus, indicating a potential target for improving cancer treatments.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!