AI Article Synopsis
- - Early-onset colorectal cancer (EOCRC) is diagnosed in people under 50 and its rates are increasing globally, potentially linked to rising obesity levels.
- - A diet high in fats, meats, and sugars (the Western diet) alters gut microbiota and disrupts normal hydrogen sulfide levels, playing a role in EOCRC development.
- - The review discusses how changes in gut bacteria due to diet can cause inflammation and damage to the colonic lining, contributing to colorectal cancer.
Article Abstract
Colorectal cancer diagnosed in individuals under 50 years old is called early-onset colorectal cancer (EOCRC), and its incidence has been rising worldwide. Simultaneously occurring with increasing obesity, this worrisome trend is partly explained by the strong influence of dietary elements, particularly fatty, meaty, and sugary food. An animal-based diet, the so-called Western diet, causes a shift in dominant microbiota and their metabolic activity, which may disrupt the homeostasis of hydrogen sulfide concentration. Bacterial sulfur metabolism is recognized as a critical mechanism of EOCRC pathogenesis. This review evaluates the pathophysiology of how a diet-associated shift in gut microbiota, so-called the microbial sulfur diet, provokes injuries and inflammation to the colonic mucosa and contributes to the development of CRC.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146533 | PMC |
| http://dx.doi.org/10.3390/nu15081966 | DOI Listing |
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