AI Article Synopsis
- Researchers used a standardized wound model and measured the mRNA expression of genes related to inflammation, healing, and blood vessel formation (angiogenesis) after applying the probiotics every two days.
- Results showed that a combination of probiotics is more effective in promoting healing and angiogenesis compared to using them alone, suggesting that an ideal treatment should include multiple probiotic strains for better healing outcomes.
Article Abstract
The probiotics UBLP-40, UBLR-58 and UBBL-64 seem to promote wound healing when applied topically. Our aim was to investigate their effect on the mRNA expression of pro-inflammatory, healing and angiogenetic factors during the healing process of a standardized excisional wound model in rats. Rats subjected to six dorsal skin wounds were allocated to Control; ; combined formula of plus ; ; and treatments, applied every two days, along with tissue collection. The pro-inflammatory, wound-healing, and angiogenetic factors of mRNA expression were assessed by qRT-PCR. We found that exerts a strong anti-inflammatory effect in relation to -, given alone or in combination; the combined regime of -, works better, greatly promoting the expression of healing and angiogenic factors than . When separately tested, was found to work better than in promoting the expression of healing factors, while seems stronger than in the expression of angiogenic factors. We, therefore, suggest that an ideal probiotic treatment should definitively contain more than one probiotic strain to speed up all three healing phases.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141733 | PMC |
| http://dx.doi.org/10.3390/nu15081822 | DOI Listing |
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