AI Article Synopsis
- The study created magnetic graphene oxide (MGO) nanohybrids by adding iron oxide nanoparticles to graphene oxide, and then modified them by attaching gentamicin sulfate (GS) through a simple chemical process.
- The GS-MGO nanohybrids retained their magnetic properties and demonstrated strong antibacterial effects against various types of bacteria, achieving up to 100% efficacy at certain concentrations.
- Additionally, the GS-MGO had impressive non-leaching and recycling capabilities, maintaining antibacterial effectiveness even after multiple uses, highlighting its potential as a sustainable antimicrobial agent.
Article Abstract
In this study, magnetic graphene oxide (MGO) nanohybrids were first prepared by loading FeO NPs onto graphene oxide (GO). Then, GS-MGO nanohybrids were prepared by grafting gentamicin sulfate (GS) onto MGO directly using a simple amidation reaction. The prepared GS-MGO had the same magnetism as MGO. They exhibited excellent antibacterial ability against Gram-negative bacteria and Gram-positive bacteria. The GS-MGO had excellent antibacterial performance against (), (), and (). When the addition concentration of GS-MGO was 1.25 mg/mL, the calculated bacteriostatic ratios against and achieved 89.8% and 100%, respectively. For , only 0.05 mg/mL of GS-MGO had an antibacterial ratio as high as 99%. In addition, the prepared GS-MGO nanohybrids also exhibited excellent non-leaching activity with good recycling antibacterial ability. After eight times antibacterial tests, GS-MGO nanohybrids still exhibited an excellent inhibition effect on , and . Therefore, as a non-leaching antibacterial agent, the fabricated GS-MGO nanohybrid had dramatic antibacterial properties and also showed great recycling ability. Thus, it displayed great potential in the design of novel recycling antibacterial agents with non-leaching activity.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143482 | PMC |
| http://dx.doi.org/10.3390/nano13081416 | DOI Listing |
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