AI Article Synopsis
- A series of new fluorinated quinoline compounds were created using Tebufloquin and various raw materials, which were structurally confirmed using advanced techniques like H NMR and HRMS.
- One specific compound, 8-fluoro-2,3-dimethylquinolin-4-yl 4-(-butyl)benzoate, was further analyzed through X-ray single-crystal diffraction.
- The antifungal activity of these compounds was tested at a concentration of 50 μg/mL, showing strong efficacy, with several compounds exhibiting over 80% effectiveness against specific fungal strains.
Article Abstract
A series of new fluorinated quinoline analogs were synthesized using Tebufloquin as the lead compound, 2-fluoroaniline, ethyl 2-methylacetoacetate, and substituted benzoic acid as raw materials. Their structures were confirmed by H NMR, C NMR, and HRMS. The compound 8-fluoro-2,3-dimethylquinolin-4-yl 4-(-butyl)benzoate () was further determined by X-ray single-crystal diffraction. The antifungal activity was tested at 50 μg/mL, and the bioassay results showed that these quinoline derivatives had good antifungal activity. Among them, compounds , , , , and exhibited good activity (>80%) against , and compound displayed good activity (80.8%) against .
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145707 | PMC |
| http://dx.doi.org/10.3390/molecules28083373 | DOI Listing |
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