AI Article Synopsis
- Osteosarcoma is the most common bone sarcoma, originating from mesenchymal tissue, and its treatment involves a team of healthcare professionals using surgery, radiotherapy, and chemotherapy.
- Despite these efforts, many patients face recurrence, especially those with metastatic disease, highlighting the need for improved treatment strategies.
- This study reviews new advances in osteosarcoma treatment, including immunotherapy and targeted therapies, but emphasizes that more research is needed to better understand their effectiveness in clinical settings.
Article Abstract
Osteosarcoma is a rare malignancy arising from mesenchymal tissue, and represents the most common bone sarcoma. The management of osteosarcoma is challenging, and requires a multidisciplinary approach. In daily clinical practice, surgery, radiotherapy, and conventional chemotherapy constitute the therapeutic armamentarium against the disease. However, a significant number of patients with initially localized osteosarcoma will experience local or distant recurrence, and the prognosis for metastatic disease remains dismal. There is a pressing need to identify novel therapeutic strategies to better manage osteosarcoma and improve survival outcomes. In this study, we present recent advances in the therapeutic management of osteosarcoma, including surgical and medical advances. The role of immunotherapy (immune checkpoint inhibitors, adoptive cellular therapy, cancer vaccines) and other targeted therapies including tyrosine kinase inhibitors is discussed; however, additional studies are required to delineate their roles in clinical practice.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143544 | PMC |
| http://dx.doi.org/10.3390/jcm12082785 | DOI Listing |
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