Background: This study aims to evaluate the use of a computer-aided, semi-quantification approach to [F]F-DOPA positron emission tomography (PET) in pediatric-type diffuse gliomas (PDGs) to calculate the tumor-to-background ratio.
Methods: A total of 18 pediatric patients with PDGs underwent magnetic resonance imaging and [F]F-DOPA PET, which were analyzed using both manual and automated procedures. The former provided a tumor-to-normal-tissue ratio () and tumor-to-striatal-tissue ratio (), while the latter provided analogous scores (, ). We tested the correlation, consistency, and ability to stratify grading and survival between these methods.
Results: High Pearson correlation coefficients resulted between the ratios calculated with the two approaches: ρ = 0.93 ( < 10) and ρ = 0.814 ( < 10). The analysis of the residuals suggested that t and t were more consistent than and . Similarly to and , the automatically computed scores showed significant differences between low- and high-grade gliomas ( ≤ 10, -test) and the overall survival was significantly shorter in patients with higher values when compared to those with lower ones ( < 10, log-rank test).
Conclusions: This study suggested that the proposed computer-aided approach could yield similar results to the manual procedure in terms of diagnostic and prognostic information.
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| http://dx.doi.org/10.3390/jcm12082765 | DOI Listing |
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