AI Article Synopsis
- The MAPK/RAS pathway is complex and involves numerous protein-protein interactions (PPIs) that play crucial roles in cell signaling.
- Researchers have been targeting KRAS and its related proteins to develop new treatments for cancers driven by KRAS mutations.
- This review discusses recent methods aimed at inhibiting RAS signaling by disrupting specific PPIs with proteins like SOS1, RAF, PDEδ, Grb2, and RAS itself.
Article Abstract
Within the MAPK/RAS pathway, there exists a plethora of protein-protein interactions (PPIs). For many years, scientists have focused efforts on drugging KRAS and its effectors in hopes to provide much needed therapies for patients with -mutant driven cancers. In this review, we focus on recent strategies to inhibit RAS-signaling via disrupting PPIs associated with SOS1, RAF, PDEδ, Grb2, and RAS.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139024 | PMC |
| http://dx.doi.org/10.3390/ijms24087373 | DOI Listing |
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