AI Article Synopsis

  • Low-level laser therapy (LLLT) is gaining popularity in orthopedic practices for promoting healing, including improving blood vessel formation and aiding in bone recovery.
  • There are various factors, like wavelength and energy density, that can affect how LLLT works at the cellular level, and its impact can vary depending on the type of cells being treated.
  • This review seeks to clarify the molecular pathways involved in LLLT's effect on bone healing, aiming to enhance its clinical use.

Article Abstract

Low-level laser therapy (LLLT) is a treatment that is increasingly used in orthopedics practices. In vivo and in vitro studies have shown that low-level laser therapy (LLLT) promotes angiogenesis, fracture healing and osteogenic differentiation of stem cells. However, the underlying mechanisms during bone formation remain largely unknown. Factors such as wavelength, energy density, irradiation and frequency of LLLT can influence the cellular mechanisms. Moreover, the effects of LLLT are different according to cell types treated. This review aims to summarize the current knowledge of the molecular pathways activated by LLLT and its effects on the bone healing process. A better understanding of the cellular mechanisms activated by LLLT can improve its clinical application.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139216PMC
http://dx.doi.org/10.3390/ijms24087094DOI Listing

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