AI Article Synopsis
- The study investigates how mefenamic acid changes the physical and chemical properties of silica aerogels, as well as the sorption characteristics of the resulting composite material.
- Advanced techniques like magic angle spinning NMR and high-pressure C NMR were used to detect mefenamic acid and measure how quickly it absorbs carbon dioxide.
- Findings show that the presence of aerogel significantly alters the conformational ratios of mefenamic acid, shifting them from 75% to 25% (in a pure state) to 22% to 78% when embedded in the aerogel.
Article Abstract
This study examines the influence of mefenamic acid on the physical and chemical properties of silica aerogels, as well as its effect on the sorption characteristics of the composite material. Solid state magic angle spinning nuclear magnetic resonance (MAS NMR) and high-pressure C NMR kinetic studies were conducted to identify the presence of mefenamic acid and measure the kinetic rates of CO sorption. Additionally, a high-pressure T-T relaxation-relaxation correlation spectroscopy (RRCOSY) study was conducted to estimate the relative amount of mefenamic acid in the aerogel's pores, and a high-pressure nuclear Overhauser effect spectoscopy (NOESY) study was conducted to investigate the conformational preference of mefenamic acid released from the aerogel. The results indicate that mefenamic acid is affected by the chemical environment of the aerogel, altering the ratio of mefenamic acid conformers from 75% to 25% in its absence to 22% to 78% in the presence of aerogel.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138679 | PMC |
| http://dx.doi.org/10.3390/ijms24086882 | DOI Listing |
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