Evaluation of the Association between Gene Polymorphisms and Breast Cancer Risk in the Bangladeshi Population.

Breast cancer is considered the most frequent cause of mortality from malignancy among females. Fibroblast growth factor receptor 2 () gene polymorphisms are highly related to the risk of breast cancer. However, no investigation has been carried out to determine the association of gene polymorphisms in the Bangladeshi population. Based on polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), this study was performed to evaluate the association of (rs1219648, rs2420946, and rs2981582) variants in 446 Bangladeshi women (226 cases and 220 controls). A significant association of the rs1219648 variant with breast malignancy was reported in additive model 1 (aOR = 2.87, < 0.0001), additive model 2 (aOR = 5.62, < 0.0001), the dominant model (aOR = 2.87, < 0.0001), the recessive model (aOR = 4.04, < 0.0001), and the allelic model (OR = 2.16, < 0.0001). This investigation also explored the significant association of the rs2981582 variant with the risk of breast cancer in additive model 2 (aOR = 2. 60, = 0.010), the recessive model (aOR = 2.47, = 0.006), and the allelic model (OR = 1.39, = 0.016). However, the rs2420946 polymorphism showed no association with breast cancer except in the overdominant model (aOR = 0.62, = 0.048). Furthermore, GTT ( < 0.0001) haplotypes showed a correlation with breast cancer risk, and all variants showed strong linkage disequilibrium. Moreover, in silico gene expression analysis showed that the level was upregulated in BC tissues compared to healthy tissues. This study confirms the association of polymorphisms with breast cancer risk.