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| http://dx.doi.org/10.1007/s00415-023-11730-1 | DOI Listing |
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The importance of synthetic pharmacotherapy for recessive cerebellar ataxias.
Expert Rev Neurother
September 2024
Service des Neurosciences, Université de Mons, Mons, Belgique.
Introduction: The last decade has witnessed major breakthroughs in identifying novel genetic causes of hereditary ataxias, deepening our understanding of disease mechanisms, and developing therapies for these debilitating disorders.
Areas Covered: This article reviews the currently approved and most promising candidate pharmacotherapies in relation to the known disease mechanisms of the most prevalent autosomal recessive ataxias. Omaveloxolone is an Nrf2 activator that increases antioxidant defense and was recently approved for treatment of Friedreich ataxia.
Identification of metabolites associated with preserved muscle volume after aneurysmal subarachnoid hemorrhage due to high protein supplementation and neuromuscular electrical stimulation.
Sci Rep
July 2024
Program in Trauma, Shock Trauma Neurocritical Care and Department of Neurology, University of Maryland School of Medicine, 22 S. Greene Street, G7K19, Baltimore, MD, 21201, USA.
Article Synopsis
- - The INSPIRE trial showed that a high protein diet combined with neuromuscular electrical stimulation helps reduce muscle loss and improves recovery after a specific type of brain bleeding (aneurysmal subarachnoid hemorrhage).
- - Researchers used blood samples to analyze metabolites (small molecules in the blood) to identify differences between standard care and the high protein diet with stimulation group, finding 18 unique metabolites.
- - Some identified metabolites, like N-acetylleucine and quinolinate, were significantly linked to maintaining muscle mass in the temporal and quadricep muscles and showed strong correlations with protein intake.
Article Synopsis
- The INSPIRE trial showed that a high protein diet combined with neuromuscular electrical stimulation can reduce muscle loss and improve function after aSAH (aneurysmal subarachnoid hemorrhage).
- Researchers used untargeted metabolomics to analyze blood samples and identify specific metabolites associated with the benefits of this treatment.
- They found 18 unique metabolites, including several that correlated positively with protein intake and are linked to maintaining muscle volume, with N-acetylleucine showing particularly strong associations.
Acetyl-DL-leucine in combination with memantine improves acquired pendular nystagmus caused by multiple sclerosis: a case report.
J Neurol
August 2023
Department of Neurology and German Center for Vertigo and Balance Disorders, Ludwig Maximilians University, Munich, Germany.
Changes in volatile flavor of yak meat during oxidation based on multi-omics.
Food Chem
March 2022
School of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang 550000, China. Electronic address:
Hydroxyl radical system combined with GC-IMS and metabolomics were used to assess the effect of oxidation on the formation of volatile flavor emitted from yak meat. The formation of volatile compounds, including heptanal, octanal, nonanal, 2,3-glutaraldehyde, 3-hydroxy-2-butanone, etc. were promoted by oxidation.
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