Purpose: Over the last years, the number of vertebral arthrodesis has been steadily increasing. The use of iliac crest bone autograft remains the "gold standard" for bone graft substitute in these procedures. However, this solution has some side effects, such as the problem of donor site morbidity indicating that there is a real need for adequate alternatives. This pilot study aimed to evaluate the usefulness of chitosan (Ch) porous 3D scaffolds incorporated with resolvin D1 (RvD1) as an alternative implant to iliac bone autograft.
Methods: We have performed bilateral posterolateral lumbar vertebral arthrodesis in a rat animal model. Three experimental groups were used: (i) non-operated animals; (ii) animals implanted with Ch scaffolds incorporated with RvD1 and (iii) animals implanted with iliac bone autograft.
Results: The collagenous fibrous capsule formed around the Ch scaffolds with RvD1 is less dense when compared with the iliac bone autograft, suggesting an important anti-inflammatory effect of RvD1. Additionally, new bone formation was observed in the Ch scaffolds with RvD1.
Conclusion: These results demonstrate the potential of these scaffolds for bone tissue repair applications.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00586-023-07725-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Advancing the timing of drainage removal: a comprehensive analysis of different drainage removal criteria in patients undergoing short-level lumbar fusion surgery.
BMC Surg
December 2024
Department of Orthopedics & Elderly Spinal Surgery, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital of Capital Medical University, Beijing, China.
Objective: To specifically evaluate the safety and benefit of different drainage removal criteria (50 ml and 100 ml per 24 h) in patients undergoing short-level lumbar fusion surgery.
Methods: Patients with degenerative lumbar diseases who underwent short level lumbar fusion with instrumentation between January 2021 and January 2023 were retrospectively recruited in the study. Based on the different criteria for drainage removal, the patients were divided into 2 groups (group A and group B).
Two-stage surgery with oblique lateral interbody fusion and posterior fixation in degenerative scoliosis with lumbosacral curve-driven degenerative lumbar scoliosis: a feasible option to prevent postoperative coronal decompensation.
J Orthop Surg Res
December 2024
Department of Orthopaedic Surgery, Beijing Xuanwu Hospital, Beijing, China.
Objective: This study aims to introduce a two-stage surgical procedure, namely oblique lateral interbody fusion (OLIF), for spinal disorders treatment. Furthermore, clinical outcomes and imaging results are analyzed between OLIF with posterior fixation and posterior lumbar interbody fusion (PLIF) with fixation for lumbosacral curve-driven degenerative lumbar scoliosis (DLS).
Methods: 146 patients with type 2 DLS who underwent OLIF or PLIF between January 2019 and November 2023 were included.
Hounsfield unit to serum pentosidine ratio predicts screw loosening after lumbar interbody fusion.
BMC Musculoskelet Disord
December 2024
Department of Orthopaedic Surgery, The Jikei University School of Medicine, 3-19-18 Nishi-shimbashi, Minato-ku, Tokyo, 105-8471, Japan.
Purpose: This study aimed to identify whether the ratio of the vertebral Hounsfield unit to serum pentosidine (H/P ratio), which reflects bone density and quality, can predict screw loosening after spinal fusion surgery.
Methods: A retrospective case-control study was conducted in 35 patients (mean age 71 ± 10.4 years, 18 men) who underwent spinal interbody fusion for lumbar spine disease between June 2020 and February 2022.
Surgical treatment of Gorham-Stout disease combined with scoliosis: a case report and literature review.
BMC Musculoskelet Disord
December 2024
Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, People's Republic of China.
Background: Gorham-Stout disease (GSD) is a rare disease characterized by osteolysis and lymphatic malformations. GSD involving the spine is exceptionally rare and lacks a standard cure. The aim of this article was to report a case of GSD with scoliosis treated via corrective surgery and medication.
View Article and Find Full Text PDFExpression of lipid metabolism and cartilage degeneration-related factors in lumbar vertebral endplate Modic changes.
Jt Dis Relat Surg
January 2025
Department of Orthopaedic Surgery, Affiliated Hospital of Hebei University, No. 212, Yuhua East Road, Baoding 071030, Hebei, China.
Objectives: This study aims to investigate the relationship between the expression of lipid metabolism and cartilage degeneration-related factors and Modic changes (MCs) of lumbar vertebral.
Patients And Methods: This prospective study included a total of 10 patients (6 males, 4 females; mean age: 60.4±8.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!