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Leukocyte Telomere Length as a Marker of Chronic Complications in Type 2 Diabetes Patients: A Risk Assessment Study.
Int J Mol Sci
December 2024
Department of Diabetes, Institute of Rural Health, 20-090 Lublin, Poland.
Telomere shortening has been linked to type 2 diabetes (T2D) and its complications. This study aims to determine whether leukocyte telomere length (LTL) could be a useful marker in predicting the onset of complications in patients suffering from T2D. Enrolled study subjects were 147 T2D patients.
View Article and Find Full Text PDFSocial Connections, Leukocyte Telomere Length, and All-Cause Mortality in Older Adults From Costa Rica: The Costa Rican Longevity and Healthy Aging Study (CRELES).
J Aging Health
January 2025
Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Objectives: To examine the association of social connections with blood leukocyte telomere length (LTL) and all-cause mortality in older Costa Ricans.
Methods: Utilizing data from the Costa Rican Longevity and Healthy Aging Study (CRELES), a prospective cohort of 2827 individuals aged 60 and above followed since 2004, we constructed a Social Network Index (SNI) based on marital status, household size, interaction with non-cohabitating adult children, and church attendance. We used linear regression to assess SNI's association with baseline LTL ( = 1113), and Cox proportional-hazard models to examine SNI's relationship with all-cause mortality ( = 2735).
A Machine Learning Classification Model for Gastrointestinal Health in Cancer Survivors: Roles of Telomere Length and Social Determinants of Health.
Int J Environ Res Public Health
December 2024
Center for Healthy Aging, Self-Management and Complex Care, College of Nursing, The Ohio State University, Columbus, OH 43210, USA.
Background: Gastrointestinal (GI) distress is prevalent and often persistent among cancer survivors, impacting their quality of life, nutrition, daily function, and mortality. GI health screening is crucial for preventing and managing this distress. However, accurate classification methods for GI health remain unexplored.
View Article and Find Full Text PDFSenescence-like Phenotype After Chronic Exposure to Isoproterenol in Primary Quiescent Immune Cells.
Biomolecules
November 2024
Molecular Toxicology Group, Department of Biology, University of Konstanz, 78457 Konstanz, Germany.
Chronic stress is associated with a higher risk for carcinogenesis as well as age-related diseases and immune dysfunction. There is evidence showing that psychological stress can contribute to premature immunosenescence. Therefore, the question arose whether chronic exposure to catecholamine could drive immune cells into senescence.
View Article and Find Full Text PDFInfluence of subclinical hypothyroidism and brain-derived neurotropic factor on telomere length dynamics in type 1 diabetic pregnancies and their newborns.
Sci Rep
January 2025
Department of Obstetrics and Gynecology, University Hospital Centre Zagreb, 10000, Zagreb, Croatia.
Thyroid dysfunctions are common in type 1 diabetes mellitus (T1DM) pregnancies, impacting embryogenesis and fetal neurodevelopment. This study investigates the effects of subclinical hypothyroidism and BDNF (Brain-derived neurotrophic factor) telomere length in T1DM mothers and their newborns. In a recent study, researchers found an inverse relationship between TSH (thyroid-stimulating hormone) levels and telomere length in the cord blood of newborns.
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