AI Article Synopsis
- - The study explored how different ratios of omega-3 (ω-3) and omega-6 (ω-6) polyunsaturated fatty acids (PUFAs) affect microglial cells, which are important for immune response in the brain, when induced by lipopolysaccharide (LPS).
- - Results indicated that specific PUFA ratios, particularly 7/1 and 2/1 ω-6/ω-3, led to more active microglial shapes and reduced secretion of tumor necrosis factor (TNF)-α compared to the control group.
- - The findings suggest that optimizing ω-6/ω-3 intake ratios could be beneficial for managing neuroinflammation and developing dietary strategies
Article Abstract
The study investigated the effect of different omega (ω)- 3 and omega (ω)- 6 polyunsaturated fatty acid (PUFA) ratios on cytokine secretion, cell viability, and microglial cell shape in lipopolysaccharide (LPS)-induced microglia. The addition of PUFAs at different ratios, especially ω-3 and ratios of 7/1 and 2/1 ω-6/ω-3, resulted in a significant increase in the ameboid form of microglial cells, as well as more branching of their distal branches. Microglial cells were treated with varying ratios of PUFAs, and their cytokine secretion was measured. The results showed that all PUFA ratios had lower tumor necrosis factor (TNF)-α secretion than the control group, higher interleukin (IL)- 4 secretion in the ω-6 group, and less IL-10 secretion most down IL-6 secretion in the 7/1 ratio group. The study suggests that determining the appropriate ω-6/ω-3 consumption ratio, especially the 7/1 and 2/1 ratios, may help manage neuroinflammation, develop dietary models in immune-mediated neurodegenerative diseases, and open up new treatment possibilities.
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| http://dx.doi.org/10.1016/j.prostaglandins.2023.106739 | DOI Listing |
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