AI Article Synopsis
- The study investigates the effectiveness of using an enhancer, nano-titanium dioxide (nano-TiO), in conjunction with photodynamic therapy (PDT) using erythrosine to treat fungal biofilms on acrylic resin.
- Researchers compared the antifungal effects of erythrosine with nano-TiO and blue light to three standard antifungal agents: nystatin, fluconazole, and Polident, by treating biofilms for 15 minutes and analyzing results at intervals of 1, 3, and 6 hours.
- Results showed that after 1 hour, all treatments were similarly effective, but at 6 hours, the combination of erythrosine, nano-TiO, and blue light significantly
Article Abstract
Objective: Incorporating an enhancer such as nano-titanium dioxide into antimicrobial photodynamic therapy can improve treatment outcome.This study aimed to compare the anticandidal efficacy of photodynamic therapy by erythrosine with nano-titanium dioxide (nano-TiO) stimulated by a blue light emitting diode with three standard dental antifungal agents.
Materials And Methods: biofilms on acrylic resin plates were treated for 15 minutes with either nystatin, fluconazole, Polident, 220µM erythrosine + 1% (w/w) nano-TiO + 15 J/cm blue light photodynamic therapy (Ery PDT), or distilled water. For the Ery PDT group, blue light was applied for 1 minute after incubation. After 1, 3, and 6 hours, the colony forming units in log10 (logCFU/mL) were compared. The ultrastructure of on the acrylic resin plates treated with erythrosine + nano-TiO + blue light was examined using transmission electron microscopy at magnification of 30,000x.
Results: After 1 hour, nystatin, Polident, and Ery PDT indifferently inhibited . At 6 hours, Ery PDT reduced the number of viable in biofilms by 0.28log CFU/mL, which was equal to the effect of fluconazole and Polident. Transmission electron microscopy demonstrated that Ery PDT altered the cell morphology by inducing cell wall/membrane rupture.
Conclusion: Photodynamic therapy with erythrosine + nano-TiO + blue light at low light power density (15 J/cm) was as effective at inhibiting biofilm on acrylic resin as fluconazole and Polident.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959592 | PMC |
| http://dx.doi.org/10.1055/s-0043-1768165 | DOI Listing |
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