Genomics expands the mammalverse.

Science

Department of Biology, Washington University, St. Louis, MO, USA.

Published: April 2023

Diverse mammal genomes open a new portal to hidden aspects of evolutionary history.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10876211PMC
http://dx.doi.org/10.1126/science.add2209DOI Listing

Publication Analysis

Top Keywords

genomics expands
4
expands mammalverse
4
mammalverse diverse
4
diverse mammal
4
mammal genomes
4
genomes open
4
open portal
4
portal hidden
4
hidden aspects
4
aspects evolutionary
4

Similar Publications

The expansion of single-cell analytical techniques has empowered the exploration of diverse biological questions at the individual cells. Droplet-based single-cell RNA sequencing (scRNA-seq) methods have been particularly widely used due to their high-throughput capabilities and small reaction volumes. While commercial systems have contributed to the widespread adoption of droplet-based scRNA-seq, their relatively high cost limits the ability to profile large numbers of cells and samples.

View Article and Find Full Text PDF

Circulating glycine levels have been associated with reduced risk of coronary artery disease (CAD) in humans but these associations have not been observed in all studies. We evaluated whether the relationship between glycine levels and atherosclerosis was causal using genetic analyses in humans and feeding studies in mice. Serum glycine levels were evaluated for association with risk of CAD in the UK Biobank.

View Article and Find Full Text PDF

Expanding Upon Genomics in Rare Diseases: Epigenomic Insights.

Int J Mol Sci

December 2024

Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905, USA.

DNA methylation is an essential epigenetic modification that plays a crucial role in regulating gene expression and maintaining genomic stability. With the advancement in sequencing technology, methylation studies have provided valuable insights into the diagnosis of rare diseases through the various identification of episignatures, epivariation, epioutliers, and allele-specific methylation. However, current methylation studies are not without limitations.

View Article and Find Full Text PDF

Recently expanded reports of multidrug-resistant fungal infections underscore the need to develop new and more efficient methods for antifungal drug discovery. A ubiquitous problem in natural product drug discovery campaigns is the rediscovery of known compounds or their relatives; accordingly, we have integrated Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for structural dereplication and Yeast Chemical Genomics for bioprocess evaluation into a screening platform to identify such compounds early in the screening process. We identified 450 fractions inhibiting and the resistant strains of and among more than 40,000 natural product fractions.

View Article and Find Full Text PDF

Genome mining is a promising avenue for expanding the repertoire of microbial natural products, which are important for drug development. This approach involves predicting genetically encoded small molecules by examining bacterial genomes via accumulated knowledge of microbial biosynthesis. However, it is also important that the microbes produce the predicted molecule in practice.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!