Seven new lobane diterpenoids, namely, lobocatalens A-G (-), were isolated from the Xisha soft coral . Their structures, including their absolute configurations, were elucidated via spectroscopic analysis, comparison with the literature data, QM-MNR, and TDDFT-ECD calculations. Among them, lobocatalen A () is a new lobane diterpenoid with an unusual ether linkage between C-14 and C-18. In addition, compound showed moderate anti-inflammatory activity in the zebrafish models and cytotoxic activity against the K562 human cancer cell line.
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Seven New Lobane Diterpenoids from the Soft Coral .
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Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
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State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; Open Studio for Druggability Research of Marine Natural Products, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:
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Further chemical investigation of the EtOAc extract of the soft coral resulted in the discovery of eleven new diterpenoids lobovarols F-P (-) of lobane- and prenyleudesmane-types, along with two known metabolites ( and ). The structures of the new metabolites were established by spectroscopic analyses, including 2D NMR experiments. The absolute configuration of was determined using Mosher's method.
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Mar Drugs
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