AI Article Synopsis
- * Results showed that 1,5-AF was quickly broken down to 1,5-AG, with peak levels of 1,5-AG appearing in the blood and urine after the substance was administered.
- * The findings indicate that 1,5-AF is effectively metabolized in both pigs and humans, suggesting its potential health benefits through this metabolic pathway.
Article Abstract
Background/aim: 1,5-Anhydro-d-fructose (1,5-AF, saccharide) and 1,5-anhydro-d-glucitol (1,5-AG) converted from 1,5-AF via the glycemic pathway have health benefits. However, this metabolism has not been sufficiently elucidated. To clarify the in vivo metabolism of 1,5-AF to 1,5-AG, porcine (blood kinetics) and human (urinary excretion) studies were conducted.
Materials And Methods: Microminipigs were administrated 1,5-AF orally or intravenously. Blood samples were obtained to analyse the kinetics of 1,5-AF and 1,5-AG. Urine samples were collected from human subjects who had orally ingested 1,5-AF, and the amounts of 1,5-AF and 1,5-AG excreted in the urine were analysed.
Results: In blood kinetics analysis, the time to the maximum concentration of 1,5-AF after intravenous administration was 0.5 h, whereas 1,5-AF was not observed after oral administration. The times to the maximum concentration of 1,5-AG after intravenous and oral administration were 1.5 h and 2 h, respectively. In urinary excretion, the concentration of 1,5-AG in urine rapidly increased after the administration of 1,5-AF, peaked at 2 h, whereas 1,5-AF was not detected.
Conclusion: 1,5-AF was rapidly metabolized to 1.5-AG in vivo in swine and human.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188028 | PMC |
| http://dx.doi.org/10.21873/invivo.13176 | DOI Listing |
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