AI Article Synopsis
- - Patients with breast cancer who also have autoimmune conditions showed a prevalence of 27% among the studied group, suggesting a notable connection between these diseases.
- - Women with stage IV breast cancer and an autoimmune diagnosis experienced significantly longer overall survival and lower cancer-specific mortality compared to those without autoimmune disorders, even after adjusting for various factors.
- - Conversely, for patients with early stages (I-III) of breast cancer, having an autoimmune diagnosis was linked to reduced overall survival, indicating that the relationship between autoimmune disease and breast cancer outcomes varies by disease stage.
Article Abstract
Background: Patients with certain autoimmune conditions are at a reduced risk of developing breast cancer compared to the general population. Despite this, little is known about outcomes in patients with breast cancer who have a concurrent autoimmune diagnosis.
Methods: This study compared differences in outcomes between women with breast cancer who had or did not have an autoimmune diagnosis. The SEER-Medicare databases (2007-2014) were used to identify patients with breast cancer and diagnosis codes were used to identify those with an autoimmune disorder.
Results: The studied autoimmune diseases had a prevalence of 27% among the 137,324 patients with breast cancer. Autoimmune disease was associated with significantly longer overall survival (OS) and significantly lower cancer-specific mortality (CSM) among stage IV breast cancer patients (p < 0.0001). After controlling for the effects of age, race, chronic kideny disease, chemotherapy, and radiation therapy autoimmune disease was still predictive of improved OS (HR: 1.45, 95% CI: 1.35-1.55, p < 0.0001) and CSM (HR: 1.40, 95% CI: 1.29-1.5, p < 0.0001). By contrast, in patients with stage I-III breast cancer, the presence of an autoimmune diagnosis was associated with a lower OS (p < 0.0001, p < 0.0001, and p = 0.026, respectively), compared to patients without autoimmune disease.
Conclusions: We found a higher prevalence of rheumatoid arthritis, Crohn's disease, ulcerative colitis, and systemic lupus erythematosus in patients with breast cancer compared to age matched cohorts in the general population. The presence of an autoimmune diagnosis was associated with a lower OS in stages I-III breast cancer and improved OS and CSM in patients with stage IV disease. These results suggest that anti-tumor immunity plays an important role in late stage breast cancer and could potentially be exploited to improve the effectiveness of immunotherapy.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10315719 | PMC |
| http://dx.doi.org/10.1002/cam4.5989 | DOI Listing |
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