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IgG-4 related disease (IgG4-RD) is an under recognised multisystem inflammatory disorder that has several typical manifestations. Cardiac manifestations of IgG4-RD are well documented however do not feature in the definition or diagnosis of IgG4-RD according to a recent consensus statement. The most well recognised cardiac manifestation of IgG4-RD, pericardial disease, is outlined in this case report as the initial presenting pathology.

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Article Synopsis
  • Takayasu's Arteritis (TA) is a rare and chronic condition affecting large blood vessels, which can result in serious heart problems and potentially life-threatening situations.
  • A 34-year-old woman with a heart murmur experienced chest pain, and imaging revealed multiple cardiac issues leading to her diagnosis of TA.
  • The case emphasizes the importance of early detection and multimodal imaging for patients with unusual symptoms and heart-related complications, especially those with valvular diseases.
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Constrictive pericarditis can lead to compromised diastolic ventricular filling due to pericardial inflammation and fibrosis. A diagnosis of constrictive pericarditis was established by identifying structural and hemodynamic features through echocardiography. We present a case of constrictive pericarditis, which manifested in the form of gradually worsening dyspnea and lower-extremity edema over a 7 years period.

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