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Tumor-derived extracellular vesicle PD-1 promotes tumor immune evasion via disruption of peripheral T cell homeostasis.
Cancer Lett
January 2025
Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Southeast University, Nanjing 210096, China. Electronic address:
The programmed cell death 1 (PD-1)/PD-1 ligand 1 (PD-L1) axis mediates immune evasion of tumor, and targeting this axis has achieved some clinical benefits. The regulation of PD-1 expression in immune cells has been well studied. However, whether any other potential source of immune cell-expressed PD-1 exists remains unknown.
View Article and Find Full Text PDFEvent-related theta synchronization over sensorimotor areas differs between younger and older adults and is related to bimanual motor control.
Neuroimage
January 2025
Movement & Neuroscience, Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.
When engaged in dynamic or continuous movements, action initiation involves modifying an ongoing motor program rather than initiating it from rest. Event-related theta synchronization over sensorimotor areas is a neurophysiological marker for modifying motor programs. We used electroencephalography (EEG) to examine how task complexity and age affect event-related synchronization (ERS) in the theta band during a dynamic bimanual, visuomotor pinch force task.
View Article and Find Full Text PDFTertiary Lymphoid Structures as a Biomarker in Immunotherapy and Beyond: Advancing Towards Clinical Application.
Cancer Lett
January 2025
. Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. Electronic address:
Tertiary lymphoid structures (TLSs) are ectopic immune cell clusters formed in nonlymphoid tissues affected by persistent inflammation, such as in cancer and prolonged infections. They have features of the structure and function of secondary lymphoid organs, featuring central CD20+ B cells, surrounded by CD3+ T cells, CD21+ follicular dendritic cells, and CD68+ macrophages, with a complex vascular system. TLS formation is governed by lymphotoxin-α1β2, TNF, and chemokines like CCL19, CCL21, and CXCL13, differing from secondary lymphoid organ development in developing later in life at sites of chronic inflammation.
View Article and Find Full Text PDFRibosomal Proteins in Ribosome Assembly.
Biomolecules
December 2024
Institute of Molecular Biosciences, University of Graz, Humboldtstrasse 50, 8010 Graz, Austria.
Ribosomes are the cellular machinery responsible for translating mRNA into proteins, a process fundamental to all domains of life from bacteria to eukaryotes [...
View Article and Find Full Text PDFWhat matters to mothers: A qualitative exploration of pain and recovery after cesarean section.
Acta Anaesthesiol Scand
March 2025
Department of Anesthesia and Intensive care, University Hospital of Southern Denmark, Kolding, Denmark.
Background: Fast recovery after cesarean section is vital since the mother not only has to take care of herself but also the newborn. Recovery scores are useful tools to measure and compare recovery; however, standardized questionnaires may miss in-depth patient experiences. What is important to women in the postoperative period after cesarean section can vary in different populations, making it crucial to understand the specific needs of one's own population.
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