Machine learning has had a significant impact on multiple areas of science, technology, health, and computer and information sciences. Through the advent of quantum computing, quantum machine learning has developed as a new and important avenue for the study of complex learning problems. Yet there is substantial debate and uncertainty in regard to the foundations of machine learning. Here, we provide a detailed exposition of the mathematical connections between a general machine learning approach called Boltzmann machines and Feynman's description of quantum and statistical mechanics. In Feynman's description, quantum phenomena arise from an elegant, weighted sum over (or superposition of) paths. Our analysis shows that Boltzmann machines and neural networks have a similar mathematical structure. This allows the interpretation that the hidden layers in Boltzmann machines and neural networks are discrete versions of path elements and allows a path integral interpretation of machine learning similar to that in quantum and statistical mechanics. Since Feynman paths are a natural and elegant depiction of interference phenomena and the superposition principle germane to quantum mechanics, this analysis allows us to interpret the goal in machine learning as finding an appropriate combination of paths, and accumulated path-weights, through a network, that cumulatively captures the correct properties of an -to- map for a given mathematical problem. We are forced to conclude that neural networks are naturally related to Feynman path-integrals and hence may present one avenue to be considered as quantum problems. Consequently, we provide general quantum circuit models applicable to both Boltzmann machines and Feynman path integrals.
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http://dx.doi.org/10.1021/acs.jctc.3c00187 | DOI Listing |
Adv Clin Exp Med
January 2025
Luddy School of Informatics, Computing and Engineering, Indiana University, Bloomington, USA.
Background: Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC). Due to the lack of symptoms until advanced stages, early diagnosis of ccRCC is challenging. Therefore, the identification of novel secreted biomarkers for the early detection of ccRCC is urgently needed.
View Article and Find Full Text PDFJ Chem Inf Model
January 2025
State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200030, P.R. China.
The rise of resistance to antiretroviral drugs due to mutations in human immunodeficiency virus-1 (HIV-1) protease is a major obstacle to effective treatment. These mutations alter the drug-binding pocket of the protease and reduce the drug efficacy by disrupting interactions with inhibitors. Traditional methods, such as biochemical assays and structural biology, are crucial for studying enzyme function but are time-consuming and labor-intensive.
View Article and Find Full Text PDFEmergencias
December 2024
Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seúl, República de Corea. Department of Digital Health, SAIHST, Sungkyunkwan University, Seúl, República de Corea.
Objective: To develop a Metabolic Derangement Score (MDS) based on parameters available after initial testing and assess the score's ability to predict survival after out-of hospital cardiac arrest (OHCA) and the likely usefulness of extracorporeal life support (ECLS).
Methods: A total of 5100 cases in the Korean Cardiac Arrest Research Consortium registry were included. Patients' mean age was 67 years, and 69% were men.
Background: Diabetic kidney disease (DKD) is one of the typical complications of type 2 diabetes (T2D), with approximately 10 % of DKD patients experiencing a Rapid decline (RD) in kidney function. RD leads to an increased risk of poor outcomes such as the need for dialysis. Albuminuria is a known kidney damage biomarker for DKD, yet RD cases do not always show changes in albuminuria, and the exact mechanism of RD remains unclear.
View Article and Find Full Text PDFJ Dent Sci
December 2024
Blood Transfusion Haematology Hospital No. 2, Ho Chi Minh City, Viet Nam.
Background/purpose: Oral squamous cell carcinoma (OSCC) is notorious for its low survival rates, due to the advanced stage at which it is commonly diagnosed. To enhance early detection and improve prognostic assessments, our study harnesses the power of machine learning (ML) to dissect and interpret complex patterns within mRNA-sequencing (RNA-seq) data and clinical-histopathological features.
Materials And Methods: 206 retrospective Vietnamese OSCC formalin-fixed paraffin-embedded (FFPE) tumor samples, of which 101 were subjected to RNA-seq for classification based on gene expression.
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