Several approaches for overcoming immunotherapy resistance in pancreatic and colorectal cancer syngeneic models were assessed using heparin and immunotherapy. Beneficial responses were attributed to heparin-induced vascular normalization, ensuing CD8+ T-cell infiltration, and M1 macrophage polarization, suggesting the potential for heparin-anchored therapies in cold tumors such as pancreatic cancer. See related article by Wei et al., p. 2525.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320458 | PMC |
| http://dx.doi.org/10.1158/1078-0432.CCR-23-0346 | DOI Listing |
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