Ciproheptadin was found to depress the activating effect of serotonin in the preoptic brain area and in the hypothalamic arquate nuclei. Blockade of the type II serotonin receptors increased the content of luteinizing hormone in the blood in dioestrus-2 stage and in the morning during pro-estrus. Microiontophoretic administration of serotonin into the thalamic arquate nuclei during the blockade decreased the luteinizing hormone level in the blood in dioestrus-2 stage and in the morning during pro-estrus. Administration of serotonin into the preoptic area under the same conditions invariably decreased the hormone level in the blood. A significant negative correlation was found between the luteinizing hormone contents in the blood and hypophysis.
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