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Comparison of Long-Term Antibody Titers in Calves Treated with Different Conjunctival and Subcutaneous S19 Vaccines.
Animals (Basel)
January 2025
Department of Microbiology, Faculty of Veterinary Medicine, Selcuk University, 42130 Konya, Turkey.
Brucellosis is still the most common zoonosis worldwide despite advanced technology and animal husbandry. Since there is still no effective vaccine for humans, it is crucial to control the disease in ruminants through eradication and vaccination. Although some countries around the world have achieved this circumstance, every country aims to become free of Brucellosis through vaccination, animal movements, and various eradication measures.
View Article and Find Full Text PDFBayesian Sample Size Calculation in Small n, Sequential Multiple Assignment Randomized Trials (snSMART).
Pharm Stat
January 2025
Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
A recent study design for clinical trials with small sample sizes is the small n, sequential, multiple assignment, randomized trial (snSMART). An snSMART design has been previously proposed to compare the efficacy of two dose levels versus placebo. In such a trial, participants are initially randomized to receive either low dose, high dose or placebo in stage 1.
View Article and Find Full Text PDFA Study on the Persistence of Immunity Following Two-Dose Varicella Vaccination With Varying Intervals in Chinese Children Aged 2-7 years.
J Med Virol
January 2025
Department of Rheumatology and Immunology, The Affiliated Suqian First People's Hospital of Nanjing Medical University, Suqian, Jiangsu, China.
Varicella, a highly contagious disease caused by the varicella-zoster virus (VZV), remains prevalent in China despite the introduction of the varicella vaccine in 1997. The current vaccination protocol in China involves a voluntary, self-funded single-dose regimen. This study aims to investigate the longevity of immune response in Chinese children following two-dose varicella vaccination administered at different intervals, with the objective of optimizing vaccination strategies.
View Article and Find Full Text PDFA practical approach to the spatial-domain calculation of nonprewhitening model observers in computed tomography.
Med Phys
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Department of Nuclear Medicine and Medical Physics, Karolinska University Hospital, Stockholm, Sweden.
Background: Modern reconstruction algorithms for computed tomography (CT) can exhibit nonlinear properties, including non-stationarity of noise and contrast dependence of both noise and spatial resolution. Model observers have been recommended as a tool for the task-based assessment of image quality (Samei E et al., Med Phys.
View Article and Find Full Text PDFEfficacy and safety of multi-target tyrosine kinase inhibitor AL2846 combined with gemcitabine in pancreatic cancer.
Invest New Drugs
January 2025
Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Key Laboratory of Digestive Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
Pancreatic cancer patients urgently need new treatments, and we explored the efficacy and safety of combination therapy with AL2846 and gemcitabine in pancreatic cancer patients. This was a single-arm, single-center, open-label phase I/IIa study (NCT06278493). The dose-escalation phase was designed to evaluate the maximum tolerated dose (MTD) of AL2846 combined with gemcitabine.
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