Metabolomics approach for the identification of bioactive compounds released from young and mature soybean upon in vitro gastrointestinal digestion and their effect on health-related bioactive properties.

Food Chem

Food Science Department, College of Agriculture and Veterinary Medicine, United Arab Emirates University, Al-Ain 15551, United Arab Emirates; Zayed Center for Health Science, United Arab Emirates University, Al-Ain 15551, United Arab Emirates. Electronic address:

Published: September 2023

AI Article Synopsis

  • The study compared the phytochemical profiles and bioactive properties of young (YS) and mature soybean (MS) through a metabolomics approach after simulated gastrointestinal digestion (SGID).
  • A total of 198 metabolites were identified, with specific amounts noted in both undigested and digested YS and MS, revealing increased metabolite complexity post-digestion.
  • The research found that both YS and MS had higher enzyme-inhibitory properties in their gastric digesta, while MS showed greater antioxidant and anti-inflammatory activities in its intestinal digesta compared to YS.

Article Abstract

The aim of the present study was to comparatively investigate the relative phytochemical profiles (phenolic content, organic and amino acids, free sugars, and other metabolites using metabolomics approach), and bioactive potentials of young (YS) and mature soybean (MS) upon in vitro simulated gastrointestinal digestion (SGID). Cumulatively, a total of 198 metabolites were identified in MS and YS, 119 metabolites in undigested YS, and a total of 136 metabolites in undigested MS, which further increased to 156 and 152 in YS and MS upon SGID, respectively. Gastric digesta of both YS and MS exhibited higher inhibitory properties towards α-amylase and DPP-IV enzymes than their intestinal digesta. Furthermore, the intestinal digesta of MS showed higher antioxidant and anti-inflammatory activities compared to the YS intestinal digesta. Overall, the results suggested that the gastrointestinal digestion of YS and MS displayed distinctive metabolic profiles together with varied bioactive potentials.

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http://dx.doi.org/10.1016/j.foodchem.2023.136050DOI Listing

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