CD151 is a transmembrane protein implicated in tumor progression and has been shown to regulate various cellular and molecular mechanisms contributing to malignancy. More recently, the role of CD151 in the tumor immune microenvironment (TIME) has gained attention as a potential target for cancer therapy. This review aims to explore the role of CD151 in the TIME, focusing on the therapeutic and clinical perspectives. The role of CD151 in regulating the interactions between tumor cells and the immune system will be discussed, along with the current understanding of the molecular mechanisms underlying these interactions. The current state of the development of CD151-targeted therapies and the potential clinical applications of these therapies will also be reviewed. This review provides an overview of the current knowledge on the role of CD151 in the TIME and highlights the potential of CD151 as a therapeutic target for cancer treatment.
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| http://dx.doi.org/10.1016/j.bbcan.2023.188898 | DOI Listing |
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School of Public Health, Qingdao University, Qingdao, China. Electronic address:
Article Synopsis
- The study investigates how exposure to diesel exhaust particles (DEP) affects thyroid health using a mouse model, revealing structural damage to the thyroid with signs like follicular rupture and colloid overflow.
- Decreased levels of proteins important for thyroid hormone production were observed, although certain thyroid hormone levels in the serum were elevated, indicating a complex response without affecting the HPT axis function.
- Further analysis found that DEP exposure disrupts thyroid cell adhesion and involves the CD151/α3β1/Rac1 signaling pathway, which plays a critical role in the mechanism of thyroid injury.
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