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http://dx.doi.org/10.1161/CIRCULATIONAHA.123.064130 | DOI Listing |
Brain Sci
December 2024
Department of Psychology, Center for Neuroscience and Behavior, Miami University, Oxford, OH 45056, USA.
Background/objectives: Rodents provide a useful translational model of fear- and anxiety-related behaviors. Previously stressed animals exhibit physiological and behavioral stress responses that parallel those observed in anxious humans. Patients diagnosed with post-traumatic stress disorder (PTSD) present with a spectrum of debilitating anxiety symptoms that result from exposure to one or more traumatic events, with individuals exposed to early adverse experiences and women having increased vulnerability for diagnoses; however, the mechanisms of this increased vulnerability remain unknown.
View Article and Find Full Text PDFBrain Behav Immun
December 2024
Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO 80309, USA; Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO 80309, USA; Center for Microbial Exploration, University of Colorado Boulder, Boulder, CO 80309, USA; Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309, USA; Department of Physical Medicine and Rehabilitation and Center for Neuroscience, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address:
The prevalence of noncommunicable inflammatory disease is increasing in modern urban societies, posing significant challenges to public health. Novel prevention and therapeutic strategies are needed to effectively deal with this issue. One promising approach is leveraging microorganisms such as Mycobacterium vaccae ATCC 15483, known for its anti-inflammatory, immunoregulatory, and stress-resilience properties.
View Article and Find Full Text PDFBMJ Open
December 2024
Department of Addictions, King's College London Institute of Psychiatry Psychology and Neuroscience, London, UK.
mBio
January 2025
Department of Systems Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Unlabelled: The bacterial toxin colibactin, produced primarily by the B2 phylogroup of , underlies some cases of colorectal cancers. Colibactin crosslinks DNA and induces genotoxic damage in both mammalian and bacterial cells. While the mechanisms facilitating colibactin delivery remain unclear, results from multiple studies supported a delivery model that necessitates cell-cell contact.
View Article and Find Full Text PDFPediatr Crit Care Med
January 2025
Pediatric Critical Care Medicine, Department of Pediatrics, Yale Medicine, New Haven, CT.
Objectives: To determine the reliability of the Bleeding Assessment Scale in critically Ill Children (BASIC) definition of bleeding severity in a diverse cohort of critically ill children.
Design: Prospective cohort study.
Setting: Eight mixed PICUs in the Netherlands, Israel, and the United States.
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