AI Article Synopsis
- The study investigates the mental health effects of a prostate cancer diagnosis, focusing on symptoms like depression, anxiety, fear of recurrence, and issues with body image and masculinity.
- MIND-P is a multi-institutional study that will follow 300 newly diagnosed prostate cancer patients over 12 months, assessing their mental and physical wellbeing through questionnaires at various intervals based on their treatment types.
- The goal is to identify significant prognostic factors affecting mental wellbeing outcomes to enhance future research and clinical practices, potentially helping doctors support patients better during follow-up care.
Article Abstract
Background: The mental wellbeing implications of a prostate cancer diagnosis are increasingly being realised. Significant mental health symptoms such as depression and anxiety, along with related constructs such as fear of cancer recurrence, body image and masculine self-esteem issues are prevalent. However, less is understood about potential prognostic factors for these outcomes in prostate cancer patients. Therefore, this study aims to primarily explore potential treatment, patient and oncological factors associated with mental wellbeing outcomes in the initial prostate cancer follow-up period.
Methods: MIND-P is a multi-institutional prospective cohort study recruiting newly diagnosed prostate cancer patients for 12-month follow up. It will aim to recruit a final sample of 300 participants undergoing one of four treatment options: active surveillance, radical prostatectomy, radical radiotherapy, or hormone monotherapy. Questionnaire-based data collection consists of multiple validated mental, physical, and social wellbeing outcomes at baseline and 3-monthly intervals until study completion. Primary analysis will include evaluation of treatment undergone against multiple mental wellbeing outcomes. Secondary analysis will additionally explore multiple patient and oncological prognostic factors of potential importance, along with the cumulative incidence of these outcomes, symptom trajectory and their association with subsequent functional and social outcomes.
Conclusion: This cohort study aims to add to the existing limited literature evaluating significant prognostic factors for multiple mental wellbeing outcomes in newly diagnosed prostate cancer patients. This may be of potential use for guiding future prognosis research and of clinical use for identifying individuals potentially requiring additional surveillance or support during routine cancer follow up.
Study Registration: This study was prospectively registered on ClinicalTrials.gov (NCT04647474).
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10124830 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0284727 | PLOS |
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