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A New Dimension in Pessary Care.
Urogynecology (Phila)
June 2023
From the Division of Urogynecology, Department of Ob/Gyn, Duke Hospital, Durham, NC.
3D Printing of Paracetamol Suppositories: An Automated Manufacturing Technique for Individualized Therapy.
Pharmaceutics
December 2022
Institute of Pharmacy, Biopharmaceutics and Pharmaceutical Technology, University of Greifswald, Felix-Hausdorff-Str. 3, 17489 Greifswald, Germany.
Pharmaceutical compounding using the molding technique is the currently applied method for the on-demand manufacturing of suppositories and pessaries. Potential errors of this method are difficult to detect, and the possibilities of individualization of size and shape of the suppositories are limited. In this study, a syringe-based semi-solid 3D printing technique was developed for the manufacturing of suppositories in three different printing designs with the suppository bases polyethylene glycol (PEG) and hard fat (HF).
View Article and Find Full Text PDFImpact of past obstetric history and cervical excision on preterm birth rate.
Acta Obstet Gynecol Scand
November 2021
Department of Obstetrics and Gynaecology, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, UK.
Introduction: To determine the impact on preterm birth (PTB) of a history of large loop excision of the transformation zone (LLETZ)-alone compared with a history of previous preterm birth-alone (PPTB) or a history of both (LLETZ+PPTB). Secondary analyses were performed to evaluate the impact of antenatal interventions, depth of cervical excision, and patient risk factors on PTB rate in each cohort.
Material And Methods: A retrospective observational cohort study of women referred to a tertiary Antenatal Prematurity Prevention Clinic with a history of LLETZ, PPTB, or LLETZ+PPTB.
Pelvic organ prolapse (POP) has a general incidence of > 10% in the female population of the Western world. The pessary is a silicone device, inserted into the vagina to provide support to the pelvic organs. It is used as a conservative treatment to improve prolapse symptoms.
View Article and Find Full Text PDFSuccess and failure are dynamic, recurrent event states after surgical treatment for pelvic organ prolapse.
Am J Obstet Gynecol
April 2021
Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC.
Background: The ideal measure of success after surgery for pelvic organ prolapse has long been debated. Historically, strict definitions based on anatomic perfection have dominated the literature. However, the importance of patient-centered perception of outcomes is equally or more important when comparing the success of various prolapse surgeries.
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