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Obsessive-compulsive symptoms and personal recovery in patients with schizophrenia spectrum disorders: A cross-sectional study.
Schizophr Res
January 2025
Department of Psychiatry, Amsterdam UMC, Amsterdam, the Netherlands; Arkin Institute for Mental Health, Amsterdam, the Netherlands.
Background: Obsessive-compulsive symptoms (OCS) frequently co-occur in patients with Schizophrenia Spectrum Disorders (SSD). Patients with SSD and OCS experience increased clinical and social challenges, including diminished quality of life and subjective well-being. However, it is unknown whether co-morbid OCS are associated with personal recovery.
View Article and Find Full Text PDFDemographics, psychiatric comorbidities, and hospital outcomes across eating disorder types in adolescents and youth: insights from US hospitals data.
Front Child Adolesc Psychiatry
May 2024
Department of Psychiatry & Behavioral Sciences, School of Medicine, Duke University, Durham, NC, United States.
Objective: The aim of our study was to delineate the differences in demographics, comorbidities, and hospital outcomes by eating disorder types in adolescents and transitional-age youth (15-26 years), and measure the association with psychiatric comorbidities.
Methods: We conducted a cross-sectional study using the nationwide inpatient sample (2018-2019) and included 7,435 inpatients (age 12-24 years) with a primary diagnosis of eating disorders: anorexia nervosa (AN, 71.7%), bulimia nervosa (BN, 4.
"Actor-critic" dichotomous hyperactivation and hypoconnectivity in obsessive-compulsive disorder.
Neuroimage Clin
December 2024
Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, 3000-548 Coimbra, Portugal; Institute for Nuclear Sciences Applied to Health (ICNAS), University of Coimbra, 3000-548 Coimbra, Portugal; Faculty of Medicine, Institute of Physiology, University of Coimbra, 3004-531 Coimbra, Portugal. Electronic address:
Dysfunctional response inhibition, mediated by the striatum and its connections, is thought to underly the clinical manifestations of obsessive-compulsive disorder (OCD). However, the exact neural mechanisms remain controversial. In this study, we undertook a novel approach by positing that a) inhibition is a dynamic construct inherently susceptible to numerous failures, which require error-processing, and b) the actor-critic framework of reinforcement learning can integrate neural patterns of inhibition and error-processing in OCD with their behavioural correlates.
View Article and Find Full Text PDF12-month neurological and psychiatric outcomes of semaglutide use for type 2 diabetes: a propensity-score matched cohort study.
EClinicalMedicine
August 2024
Department of Psychiatry, University of Oxford, Warneford Hospital, Warneford Lane, Oxford, OX3 7JX, United Kingdom.
Background: While semaglutide, approved for type-2 diabetes mellitus (T2DM), is being investigated as a treatment for brain disorders, concerns over adverse neuropsychiatric events have emerged. More data are therefore needed to assess the effects of semaglutide on brain health. This study provides robust estimates of the risk of neurological and psychiatric outcomes following semaglutide use compared to three other antidiabetic medications.
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