Environmental microplastics have emerged as a critical issue in maintaining the planetary ecosystem. In this study, we generated particulate microplastics from polyethylene terephthalate (PM-PET) and investigated their impact in the gut by using mouse models and implementing histological examinations, as well as multi-omics analysis for colonic immune cells and microbiota. As a result, histological approaches showed that chronic and physiological low dose exposure of PM-PET did not affect intestinal pathology and mucin barriers, respectively. Moreover, immunohistochemical analysis demonstrated that the numbers of T cells, B cells, macrophages, and granulocytes were not affected by the exposure to PM-PET. However, RNA-seq analysis revealed that PM-PET had a substantial impact on the transcriptome in gut immune cells and their metabolisms, while 16s rRNA metagenomic analysis showed that the composition of microbiota was modestly affected. These results suggest an unexpected role played by the PM-PET in affecting gut immune homeostasis without detectable inflammation.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113781 | PMC |
| http://dx.doi.org/10.1016/j.isci.2023.106474 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Recent developments on aerial lab-on-a-drone platforms for remote environmental monitoring: A review.
Anal Chim Acta
February 2025
Instituto de Química, Universidade Federal de Goiás, 74690-900, Goiânia, GO, Brazil; Instituto Nacional de Ciência e Tecnologia de Bioanalítica, Campinas, 13084-971, SP, Brazil. Electronic address:
Background: Distinct classes of environmental contaminants - such as microplastics, volatile organic compounds, inorganic gases, hormones, pesticides/herbicides, and heavy metals - have been continuously released into the environment from different sources. Anthropogenic activities with unprecedented consequences have impacted soil, surface waters, and the atmosphere. In this scenario, developing sensing materials and analytical platforms for monitoring water and air quality is essential to supporting worldwide environmental control agencies.
View Article and Find Full Text PDFComplicated pollution characteristics (particulate matter, heavy metals, microplastics, VOCs) of spent lithium-ion battery recycling at an industrial level.
Sci Total Environ
January 2025
School of Environmental Science and Engineering, Shanghai Jiao Tong University, 200240, China.
The recycling of spent lithium-ion batteries has become a common concern of the whole society, with a large number of studies on recycling management and recycling technology, but there is relatively little study on the pollution release during the recycling process. Pollution will restrict the healthy development of the recycling industry, which makes relevant research very significant. This paper monitored and analyzed the battery recycling pretreatment process in a formal factory, and studied the pollution characteristics of particulate matter, heavy metals, and microplastics under different treatment stages.
View Article and Find Full Text PDFRising Concern About the Carcinogenetic Role of Micro-Nanoplastics.
Int J Mol Sci
December 2024
Department of Oncology, Luigi Sacco University Hospital, ASST Fatebenefratelli Sacco, 20157 Milan, Italy.
In recent years, awareness regarding micro-nanoplastics' (MNPs) potential effects on human health has progressively increased. Despite a large body of evidence regarding the origin and distribution of MNPs in the environment, their impact on human health remains to be determined. In this context, there is a major need to address their potential carcinogenic risks, since MNPs could hypothetically mediate direct and indirect carcinogenic effects, the latter mediated by particle-linked chemical carcinogens.
View Article and Find Full Text PDFThe combined effects of microplastics and their additives on mangrove system: From the sinks to the sources of carbon.
Sci Total Environ
January 2025
College of Environmental Science and Engineering, Tongji University, State Key Laboratory of Pollution Control and Resource Reuse, Ministry of Education Key Laboratory of Yangtze River Water Environment, Shanghai 200092, China; Frontiers Science Center for Intelligent Autonomous Systems, Shanghai 200092, China; Institute of Carbon Neutrality, Tongji University, Shanghai 200092, China. Electronic address:
Mangrove ecosystems, a type of blue carbon ecosystems (BCEs), are vital to the global carbon cycle. However, the combined effects of microplastics (MPs) and plastic additives on carbon sequestration (CS) in mangroves remain unclear. Here, we comprehensively review the sources, occurrence, and environmental behaviors of MPs and representative plastic additives in mangrove ecosystems, including flame retardants, such as polybrominated diphenyl ethers (PBDEs), and plasticizers, such as phthalate esters (PAEs).
View Article and Find Full Text PDFEnvironmental release behavior, cell toxicity and intracellular distribution of novel biodegradable plastic materials.
Environ Pollut
December 2024
Tianjin Key Laboratory of Urban Transport Emission Research, State Environmental Protection Key Laboratory of Urban Ambient Air Particulate Matter Pollution Prevention and Control, College of Environmental Science and Engineering, Nankai University, Tianjin, 300071, China. Electronic address:
In response to the increasingly severe issue of plastic waste, biodegradable plastics have garnered extensive attention as a potential alternative to traditional plastics. Among these materials, biodegradable plastics hold a dominant position. The objective of this study was to assess the environmental risks of five commercially available biodegradable plastics: polyglycolic acid (PGA), polylactic acid (PLA), poly(butylene succinate) (PBS), poly(butylene carbonate) (PBC), and poly(butylene adipate-co-terephthalate) (PBAT).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!