Benign paroxysmal positional vertigo (BPPV) is the peripheral vestibular disorder that is most frequently encountered in routine neuro-otological practice. Among the three semicircular canals, the lateral semicircular canal (LSC) is the second most frequently interested in the pathological process. In most cases, LSC BPPV is attributable to a canalithiasis or cupulolithiasis mechanism. The clinical picture of LSC BPPV is that of positional nystagmus and vertigo evoked by turning the head from the supine to the side lateral position. With such a movement, a horizontal positional (and often also paroxysmal) direction-changing nystagmus is generated. Depending on whether the pathogenetic mechanism is that of canalithiasis or cupulolithiasis and depending on where the dense particles are located, LSC BPPV direction-changing positional nystagmus is geotropic or apogeotropic on both lateral sides. Due to its mechanical nature, BPPV is effectively treated by means of physical therapy. In the case of a LSC BPPV, one of the most effective therapies is the forced prolonged position (FPP), in which the patient is invited to lie for 12 h on the lateral side on which vertigo and nystagmus are less intense, to move the canaliths out from the canal (or to shift them inside of the canal from one tract to another) exploiting the force of gravity. Despite its efficacy, FPP is not always well tolerated by every patient, and it cannot be done during the diagnostic session because of its duration. The present study aimed to verify the efficacy of a different forced position, shortened forced position (SFP), with respect to the original FPP. SFP treatment would allow patients to more easily bear the forced position and physicians to control the outcome almost immediately, possibly enabling them to dismiss patients without vertigo. After 1 h of lying on the side where vertigo and nystagmus are the less intense, 38 out of 53 (71.7%) patients treated with SFP were either healed or improved. Although the outcomes are not as satisfying as those of the original FPP, SFP should be considered as a therapeutic prospect, especially by those physicians who work in collaboration with emergency departments or otherwise encounter acute patients to cure them of vertigo as soon as possible.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117761 | PMC |
http://dx.doi.org/10.3389/fneur.2023.1153491 | DOI Listing |
Pract Radiat Oncol
December 2024
Department of Radiation Oncology, Willis Knighton Cancer Center, 2600 Kings Highway, Shreveport, Louisiana, USA 71103 &, Department of Clinical Research, University of Jamestown, Fargo, ND, USA. Electronic address:
Purpose: Motion management presents a significant challenge in thoracic stereotactic ablative radiotherapy (SABR). Currently, a 5.0 mm standard planning target volume (PTV) margin is widely used to ensure adequate dose to the tumor.
View Article and Find Full Text PDFBioDrugs
December 2024
Antibody Engineering Department, Genentech Inc, South San Francisco, USA.
After decades of gradual progress from conceptualization to early clinical trials (1960-2000), the therapeutic potential of bispecific antibodies (bisp Abs) is now being fully realized. Insights gained from both successful and unsuccessful trials are helping to identify which mechanisms of action, antibody formats, and targets prove most effective, and which may benefit from further refinement. While T-cell engagers remain the most commonly used class of bisp Abs, current efforts aim to increase their effectiveness by co-engaging costimulatory molecules, reducing escape mechanisms, and countering immunosuppression.
View Article and Find Full Text PDFInt Rev Psychiatry
November 2024
Department of Forensic Psychiatry, University of Bern, Bern, Switzerland.
In an era marked by escalating international crises, environmental shifts, and sociopolitical volatilities, global mental health is facing profound challenges. With its distinctive position at the intersection between clinical and judicial domains, forensic psychiatry can be predisposed to the consequences of adverse external determinants and events. At present, geopolitical conflicts, rising insecurities, climate change, forced and voluntary migration, and regressive sociopolitical ideologies are all compounding role responsibilities, care models, and ethical expectations across forensic-psychiatric practice; in short, complex distal factors are increasingly informing domestic considerations.
View Article and Find Full Text PDFSci Rep
December 2024
Choremeion Research Laboratory, 1st Department of Paediatrics, Medical School, National and Kapodistrian University of Athens, 11527, Athens, Greece.
We describe a biophysical mechanism for animal magnetoreception, orientation and navigation in the geomagnetic field (GMF), based on the ion forced oscillation (IFO) mechanism in animal cell membrane voltage-gated ion channels (VGICs) (IFO-VGIC mechanism). We review previously suggested hypotheses. We describe the structure and function of VGICs and argue that they are the most sensitive electromagnetic sensors in all animals.
View Article and Find Full Text PDFJ Bodyw Mov Ther
October 2024
Department of Rehabilitation, Faculty of Health Sciences, Naragakuen University, Nara, Japan.
Introduction: The activities of external oblique (EO) and internal oblique (IO) muscles during forced expiration in a trunk-neutral posture are insufficient for muscle strengthening. Furthermore, these activities during forced expiration may be affected by trunk postures, which can change respiratory muscle activity. Therefore, this study aimed to evaluate the effects of trunk posture on the EO and IO muscles' activities during forced expiration.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!