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The effects of age on neural correlates of recollection: transient versus sustained fMRI effects. | LitMetric

AI Article Synopsis

  • A study examined how recollection-related brain activity differs between young and older adults during a memory task involving word-object pairs.
  • Older participants showed poorer associative memory performance compared to younger ones, even though similar patterns of brain activity were observed in both age groups.
  • The findings suggest that different neural regions react distinctly over time during recollection, with some effects being consistent throughout adulthood.

Article Abstract

Prior fMRI findings in young adults indicate that recollection-sensitive neural regions dissociate according to the time courses of their respective recollection effects. Here, we examined whether such dissociations are also evident in older adults. Young and older participants encoded a series of word-object image pairs, judging which of the denoted objects was the smaller. At test, participants first judged whether a test word was old or new. For items judged old, they were required to recall the associated image and hold it in mind across a variable delay period. A post-delay cue denoted which of three judgments should be made on the retrieved image. Older adults demonstrated significantly lower associative memory performance than young adults. Replicating prior findings, transient recollection effects were identified in the left hippocampus, medial prefrontal cortex and posterior cingulate, while sustained effects were widespread across left lateral cortex and were also evident in the bilateral striatum. With the exception of those in the left insula, all effects were age-invariant. These findings add to the evidence that recollection-related BOLD effects in different neural regions can be temporally dissociated. Additionally, the findings suggest that both transient and sustained recollection effects are largely stable across much of the healthy adult lifespan.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120722PMC
http://dx.doi.org/10.1101/2023.04.12.536508DOI Listing

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