The impact of ceramide glucosyltransferase enzymes on the beneficial effects of lifespan.

Ceramide glucosyltransferase (CGT) adds sugar moieties to ceramide, forming glucosylceramides that play roles in immune signaling, stress response, and host-bacterial interactions. Here, we examined whether mutations in block the beneficial effects of on lifespan. We found that loss of or reduces lifespan compared to wildtype worms, but did not prevent the lifespan-extending phenotype of . However, and did play a minor role in blocking stress resistance of 5-day old worms treated with . Further studying CGTs may elucidate potential roles of glucosylceramides in host-bacterial interaction.